The development of postgraduate course cases for clinical pharmacy plays a pivotal role in facilitating professional knowledge acquisition for postgraduate students majoring in this discipline. The Kern Six-Step Approach serves as an innovative paradigm for curriculum construction, comprising six core components: needs assessment, objective formulation, content design, implementation strategies, evaluation and feedback, and continuous improvement. This paper reviews the existing challenges in the construction of course cases for postgraduate clinical pharmacy programs, the implementation procedures, current application status, as well as the effectiveness evaluation of the Kern Six-Step Teaching Approach.