Recent Articles
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September 20, 2024 Research ArticleAbstract Therapeutic drug monitoring (TDM) studies are generally focused on keeping chronic drug exposure to minimal effective blood levels to better control compliance and to avoid side effects. The usefulness of TDM applied to new generation antipsychotics .....
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September 20, 2024 Research ArticleAbstract Cisplatin is a platinum-based chemotherapeutic that causes acute kidney injury in over 30% of patients. The aim of this study was to develop a population pharmacokinetic/toxicodynamic (PKTD) model of cisplatin-induced kidney injury that incorporates .....
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August 30, 2024 Case ReportAbstract Microplastics becomes an important threat to environment and to humans due to negative impacts on health. Sunlight is known to be the natural energy source that degrades plastic waste at a very slow rate. Based on sunlight, the photocatalytic degrada.....
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May 09, 2024 Case ReportAbstract Our case report describes the successful management of a rare case of massive dabigatran overdose using haemodialysis. There is limited literature and guidelines available to date about the toxicity of dabigatran, monitoring of anticoagulation effe.....
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February 16, 2024 Review ArticleAbstract Hepatitis is a viral infection primarily affecting the liver, causing inflammation and potentially leading to liver damage or failure. It can be caused by different hepatitis viruses, with symptoms ranging from mild to severe and can be acute or ch.....
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August 18, 2023 Research ArticleAbstract The Main protease (Mpro) is a vital enzyme of COVID-19 and plays an essential role, making it an attractive antiviral drug target. The antibiotic azithromycin was proven to be effective against influenza, remdesivir is a broad-spectrum antiviral agen.....
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August 05, 2023 Case ReportAbstract Abstract Tizanidine is a centrally acting imidazoline derivative with a novel mechanism of action, closely resembling clonidine in its structure and pharmacological mechanism. Tizanidine has Federal Drug Agency (FDA) approval for the use of muscle sp.....
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March 31, 2023 Short CommunicationAbstract Ketamine is a N-methyl-D-aspartate glutamate receptor antagonist that has efficacy against chronic major depression. Its mechanism of action likely depends on changes in glutamate-mediated transmission and plasticity in circuits involved in a wide ra.....
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February 26, 2023 Review ArticleAbstract Achieving an effective antimicrobial concentration of a broad spectrum drug by conventional oral or topical route is limited by the barriers of the eye. Systemic drugs are often underused or exploited for ocular use without rationalizing the penetrat.....
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February 26, 2023 Research ArticleAbstract Background: Citrus jabara is a type of citrus fruit originally grown in Kitayama-Mura in Wakayama, Japan, and is reputed to have anti-allergic properties. In this study, we tested whether citrus jabara juice inhibits inflammatory mediators in a mouse.....
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August 20, 2015 Review ArticleAbstract Advances in the oncological sciences have led to the development of agents that are designed to affect specific molecular pathways. However, many of these immunotherapeutic agents do not successfully pass phase 2 trials due to concerns with efficacy,.....
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July 22, 2014 Research ArticleAbstract Objective: To assess safety, tolerability, pharmacokinetics, and pharmacodynamics of JNJ-38893777, a potent and selective transient receptor potential vanilloid 1 channel antagonist, following ascending single oral administration in healthy men. Me.....
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June 06, 2014 Research ArticleAbstract We investigated the interactions between Thioredoxin (Trx) and BNP7787 (Tavocept®). BNP7787 is a water-soluble disulfide that appears well-tolerated and nontoxic, and in separate randomized multicenter Phase 2 and Phase 3 clinical trials in NSCLC pa.....
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March 04, 2014 Research ArticleAbstract Trioxanes are the new antimalarial series of potent compound having the capability to harness the over growing menace of malaria and its acquisition of resistance. In this manuscript the authors have presented results of the metabolic studies of a po.....
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March 04, 2014 Research ArticleAbstract Allometric principles were used to discern cross-species differences in (±)-tramadol disposition and formation of its primary analgesic metabolite, (±)-O-desmethyl-tramadol (M1). Species differences in formation of M1 may help predict the analgesic.....
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February 28, 2014 Research ArticleAbstract Background: Therapeutic drug monitoring (TDM) guidance suggests that lopinavir trough concentration < 1 or < 3 mcg/mL may be associated with virologic failure. The aim of this analysis was to evaluate the association between lopinavir exposure and vi.....
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January 17, 2014 Research ArticleAbstract Background: Vancomycin dosing to achieve the area-under-the-curve to minimum inhibitory concentration (AUC/MIC) target of ? 400 in children with renal insufficiency is unknown. Our objectives were to compare vancomycin clearance (CL) and initial dosi.....
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July 28, 2017 Research ArticleAbstract Introduction: Acinetobacterbaumannii (A. baumannii) is a Gram-negative coccobacillus and is a frequent cause of hospital-acquired infections. Because some strains of A. baumannii are resistant to many antibiotics (i.e., extensively drug resistant A. .....
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November 06, 2013 Research ArticleAbstract This study was designed to develop buffered thermoreversible gel containing tenofovir (TNF) loaded PLGA nanoparticles for sustained drug release and prolonged protection from HIV-1 sexual transmission. Optimized buffered thermoreversible formulation .....