AbstractCaptopril is a potent angiotensin-converting enzyme inhibitor with a Ki of 1.7 nM. Captopril may be administered orally or intravenously and the oral bioavailability is about 75%. Most of the drug is eliminated in urine, 40 to 50% as captopril, and t.....
AbstractComputational techniques in drug discovery and vaccine prediction basically revolve around molecular docking to retrieve perfect interaction models for ligand and receptor. Binding energies can be obtained for perfectly interacting complexes. Many to.....
AbstractIntroduction: Ibuprofen was associated with hypoglycemia in a single published case report in a diabetic patient. It, however, has never been associated so far with hypoglycemia in previously healthy non-diabetic individuals and thus, it is not liste.....
AbstractAcetaminophen (Paracetamol) has been used in Western medicine for more than one hundred years. By all measures, when taken as directed it is both efficacious and safe. The analgesic’s recently-discovered properties go well beyond reducing fever and.....
AbstractIntroduction: Carbamazepine (Tegretol®) (CBZ), has been available for half a century suggesting all that needs to be said has been said but it has truly withstood the test of time.
History revisited: CBZ was discovered during the research and dev.....
AbstractObjective: The aim of this study was to examine the relationship between obestatin and malnutrition in patients with chronic renal failure (CRF).
Method: The study included 43 hemodialysis patients with chronic renal failure aged >18 years and 43 .....
AbstractBackground: Neoadjuvant chemotherapy is an innovative approach that has got significant attention for treating breast cancer. Optimal management of locally advanced breast cancer (LSBC), generally includes a combination of neoadjuvant chemotherapy fo.....
