Hepatitis is a viral infection primarily affecting the liver, causing inflammation and potentially leading to liver damage or failure. It can be caused by different hepatitis viruses, with symptoms ranging from mild to severe and can be acute or chronic. This study explores the environmental factors exacerbating hepatitis transmission, particularly in regions with poor sanitation and limited access to clean water. The research found a complex relationship between ecological conditions and the spread of hepatitis A virus (HAV) and hepatitis E virus (HEV). Some identified factors include poor water quality and utilisation methods, sanitation, and practices. Other factors exacerbating hepatitis transmission include the healthcare system practices, climate and weather conditions, faecal-oral processes, occupational exposure, crowded and overpopulated areas, migration and travel. Therefore, environmental factors that can exacerbate hepatitis infection are multifaceted, and these factors may pose public health challenges. Therefore, there is a need for a holistic approach, incorporating sanitation improvements, hygiene practices, vaccination programmes, and awareness campaigns to combat hepatitis spread in diverse environmental contexts effectively.