Role of Haemodialysis in the Management of Dabigatran Overdose - Abstract
Our case report describes the successful management of a rare case of massive dabigatran overdose using haemodialysis. There is limited
literature and guidelines available to date about the toxicity of dabigatran, monitoring of anticoagulation effect, and treatment options. Symptoms
of overdose may include excessive bleeding from various sites. Idarucizumab is used as an antidote to reverse the action of dabigatran in case
of emergency procedures or uncontrolled bleeding but the dose required and utility in case of intentional overdose remains unclear. Immediate
availability of this antidote in case of acute dabigatran overdose may be challenging in many centers. Hence haemodialysis can be used as a rescue
measure to prevent life-threatening haemorrhagic complications. However, the threshold for initiating haemodialysis is not yet well defined in a
patient with normal renal function.