Myotonic Dystrophy Patient Journey: Increased Use of Healthcare Resources in the Year Prior to Diagnosis as Evidenced by Insurance Claims
- 1. Department of Physiology, Cellular and molecular Biology, Northwestern University - The Feinberg School of Medicine Carlsbad, USA
- 2. Department of Neurology, Stanford University Medical Center, USA
- 3. Department of Avidity Biosciences, Stanford University Medical Center, USA
- 4. Department of Physiology, University of California, USA
- 5. Department of Science & Health System Finance, University of Rensselaer Polytechnic Institute, USA
- 6. Department of Mathematical Sciences, Johns Hopkins University, USA
- 7. Department of Biostatistics, University of California Los Angeles, USA
- 8. Department of Physiology, Cellular and molecular Biology, Albert Einstein College of Medicine of yeshiva University, USA
Abstract
Myotonic dystrophy (DM) is an inherited autosomal dominant disease with progressive myopathy and comorbidities involving multiple organ systems. There is no cure, but a deeper understanding of the patient journey, the use of healthcare resources, and the cost of care before and after diagnosis would assist in managing supportive care. This longitudinal analysis of medical and pharmacy insurance claims between January 2010 and March 2021 included 1,694 patients with two or more DM diagnostic claims compared with 8,470 matched control (MC) patients who were propensity-score matched by index date (i.e., month of diagnosis), age, region, sex, plan, and payer type. Eligible patients had a minimum of 12 months of continuous data. Comorbidities consistent with the clinical profile of DM were more prevalent in patients with DM than in the MC cohort. The aggregate per-member-per-year medical costs were $18,239 for a patient with DM and $5,609 for a MC. The corresponding pharmacy costs were $3,029 and $1,478. Overall, resource utilization – including emergency departments, inpatient facilities, outpatient facilities, office practices, pharmacies, laboratories, procedures (Healthcare Common Procedure Coding System or Current Procedural Terminology codes), prescription medications, and clinician-administered drugs (J-codes) – and their associated costs were higher for patients with DM than MCs. Until a diagnosis of DM is established, the varied presentations of this multisystemic disorder complicates diagnostic testing and medical care. During the pre-diagnosis period, patients, caregivers, and families experience the stress and additional cost burden associated with the uncertainty of an undiagnosed condition. To further elucidate the impact of DM, additional analyses are ongoing to assess changes in comorbidities, use of healthcare resources, and costs.
Keywords
Healthcare costs; Healthcare resource utilization; Insurance claims database; Rare disease; Myotonic dystrophy; Patient journey
Citation
Tai LJ, Day JW, Munoz KA, Chen CY, Brook RA, et al. (2023) Myotonic Dystrophy Patient Journey: Increased Use of Healthcare Resources in the Year Prior to Diagnosis as Evidenced by Insurance Claims. Int J Rare Dis Orph Drugs 6(2): 1017.
ABBREVIATIONS
AHRQ: Agency for Healthcare Research and Quality; ATC: Anatomical Therapeutic Chemical; DM: Myotonic Dystrophy; CCI: Charlson Comorbidity Index; CPI: Consumer Price Index; CTP: Current Procedural Terminology; DMPK: Dystrophica Myotonica Protein Kinase; ED: Emergency Department; HCPCS: Healthcare Common Procedure Coding System; ICD-9: International Classification of Disease Ninth Revision; ICD-10: International Classification of Disease Tenth Revision; MC: Matched Control; PMPY: Per Member Per Year; SD: Standard Deviation.
INTRODUCTION
Myotonic dystrophy (DM) is the most common form of muscular dystrophy in adults. It is a rare, inherited autosomal dominant disease with progressive myopathy, myotonia, and multiorgan involvement. Comorbidities may involve the respiratory, gastrointestinal, cardiac, and central nervous systems, among others, resulting in a disease burden that has significant impact on patient and family quality of life [1-3]. Two distinct forms of DM have been identified: DM1, or Steinert’s disease, and DM2. They have clinical and pathophysiologic similarities that appear at various ages and times during the disease continuum, but they are different disorders that require genetic diagnostic testing for confirmation. Genetic screening is possible but has not been performed in large populations [4]. The most frequently cited estimate of the prevalence of DM1 is 1 in 8,000 people worldwide [5], while a more recent systematic review estimated the worldwide prevalence of DM as 0.5–18.1 per 100,000 people, without differentiating between types [6]. The prevalence of DM2 appears to be lower than that of DM1, except for populations originating from Northern Europe [7]. The epidemiology of DM has not been systematically studied in the USA, but clinical experience suggests that DM2 is approximately 5-fold less prevalent than DM1 [4]. Rarity, variable presentation, and neuromuscular features that are shared with other diseases complicate diagnosis after the onset of the initial symptoms and result in a long patient journey. There is no cure or diseasemodifying treatment, but establishing a focused, comprehensive approach to clinical care can extend patient lifespan and help maintain mobility and quality of life. Longitudinal data on the use of medical resources by patients with DM prior to diagnosis would add to what is known about the use of available resources, clinical experience, and the cost of medical care. This study analyzed healthcare claims paid during the 12 months before diagnosis (pre-index period). Identifiable claim codes were analyzed to allow in-depth views of the prevalence and costs of comorbid conditions, product use, and procedures prior to patients’ diagnosis of DM and in a matched control (MC) group.
METHODS
Study design
This study was a longitudinal analysis of medical and pharmacy claims made by insured patients between January 2010 and March 2021 and retrieved from the IQVIA US PharMetrics® Plus database [Figure 1].
Figure 1: Study plan and patient selection. The analysis included medical and pharmacy claims made by insured patients between January 2010 and March 2021. Abbreviations: DM: myotonic dystrophy; ICD-9: International Classification of Disease Ninth Revision; ICD-10: International Classification of Disease Tenth Revision
The claims data were de-identified, and the study did not influence patient care; consequently, the study was exempt from institutional review board approval. The analysis compared a cohort of patients with DM who were identified by claims including International Classification of Disease Ninth Revision (ICD-9) code 359.21 and Tenth Revision (ICD-10) code G71.11 diagnosis codes for myotonic muscular dystrophy without distinguishing type 1 and type 2 DM. Eligible patients had ≥ 2 DM diagnosis claims filed ≥ 30 days apart. The index date was used as a proxy for initial diagnosis of DM, and eligible patients had a minimum of 12 months of continuous data prior to their index date. The patients with DM were compared with a 5% random sample of patients remaining in the PharMetrics® Plus database records after excluding the DM cohort. Patients with ICD-9 359. xx (muscular dystrophies and other myopathies), ICD-10 G71. xxx (primary disorders of muscles), ICD-10 M62.5xx (muscular wasting and disuse atrophy), or ICD-10 M63.8xx (other muscle disorders in disease classified elsewhere) claims were excluded from the MC cohort. Each patient with DM was matched by index month, baseline age, region, sex, plan, and payer type to five MCs using a propensity-score-matching algorithm and nearestneighbor matching (R MatchIt) [8]. Resource utilization was reported in each cohort as the percentage of patients with relevant claims during the pre-index period. For analysis, plan costs plus member-paid costs and days or number of billed services were aggregated for each patient over the 12 months preceding the index date and reported as per-member-per-year (PMPY) values. Costs were inflation-adjusted to December 2020 dollars using the US Bureau of Labor Statistics Consumer Price Index (CPI); medical claims used the medical-cost CPI, and prescription claims used the prescription-cost CPI. The ICD-9 and ICD-10 claims included in the database were assigned and aggregated into 283 specific US Agency for Healthcare Research and Quality (AHRQ) categories (https://hcup-us.ahrq.gov/toolssoftware/ ccsr/DXCCSR-User-Guide-v2019-1.pdf). The categories were used to compare the prevalence of comorbid conditions, reasons for inpatient admissions and emergency department (ED) visits, and related costs and services. As general measures of comorbidity, Charlson Comorbidity Index (CCI) scores [9] were also calculated, along with the number of patients with CCIs >1, the per-patient number of diagnoses (ICD-9s and ICD10s), and the per-patient number of AHRQ condition categories. The utilization, PMPY cost, and number of prescription fills in each cohort were compared using the Anatomical Therapeutic Chemical (ATC) drug hierarchy classification of the World Health Organization (https://www.who.int/tools/atc-ddd-toolkit/atcclassification). Injectable drugs that are not ordinarily selfadministered (i.e., are clinician-administered) were identified by their J-codes in the medical claims. Medical procedures were identified by Healthcare Common Procedure Coding System (HCPCS) and Current Procedural Terminology (CPT) codes.
Statistical analysis
The statistical analysis was descriptive. Results were reported as means ± standard deviation or numbers and percentage. Comparisons of utilization, cost, number of services, and number of days of service in the 12 months prior to the index date were made with two-sample t-tests for continuous variables and chi-square tests for discrete variables. Differences were considered significant at p ≤ 0.01.
Result
Descriptive characteristics of patients with DM
We identified 1,694 patients with DM in the claims database and matched them to 8,470 MCs. The age, region, sex, insurance plan, and payer type of the patients with DM and MCs are shown in Table 1.
Table 1: Age, sex, US region, insurance plan, and payer types of patients with DM and MCs on the index date
|
|
Patients with DM |
MCs (n = 8,470) |
||
|
Characteristic |
Mean ± SD or % |
Mean ± SD or % |
Difference, % |
P-value |
|
Age, years |
43.4 ± 18.1 |
43.5 ± 18.2 |
−0.1 |
0.7823 |
|
< 18 |
10.8 |
10.9 |
−0.1 |
0.8980 |
|
18 to ≤ 35 |
19.3 |
19.0 |
0.3 |
0.7603 |
|
35 to ≤ 45 |
18.2 |
18.2 |
0.0 |
0.9908 |
|
45 to ≤ 55 |
20.1 |
19.9 |
0.2 |
0.8591 |
|
55 to ≤ 65 |
23.0 |
23.1 |
−0.1 |
0.9078 |
|
> 65 |
8.6 |
8.9 |
−0.3 |
0.7078 |
|
Sex, female |
50.5 |
50.7 |
−0.2 |
0.8731 |
|
US region |
|
|
|
|
|
South |
30.5 |
30.4 |
0.1 |
0.9155 |
|
Midwest |
28.5 |
28.5 |
0.0 |
0.9686 |
|
Northeast |
20.8 |
21.1 |
−0.3 |
0.8024 |
|
West |
18.5 |
18.3 |
0.2 |
0.8274 |
|
Unknown |
1.7 |
1.7 |
0.0 |
0.9190 |
|
Insurance |
|
|
|
|
|
Preferred provider organization |
66.0 |
65.9 |
0.1 |
0.9329 |
|
Health maintenance organization |
23.0 |
22.8 |
0.2 |
0.8657 |
|
Point of service plan |
5.4 |
5.7 |
−0.3 |
0.6725 |
|
Consumer-directed healthcare |
2.8 |
2.9 |
−0.1 |
0.7706 |
|
Indemnity/traditional plan |
1.6 |
1.6 |
0.0 |
0.9146 |
|
Unknown |
1.2 |
1.2 |
0.1 |
0.8380 |
|
Payer |
|
|
|
|
|
Commercial |
60.3 |
60.7 |
−0.4 |
0.7784 |
|
Self-insured |
21.5 |
21.6 |
−0.1 |
0.9227 |
|
Medicaid |
9.0 |
9.0 |
0.0 |
0.9506 |
|
Medicare advantage |
5.5 |
5.0 |
0.5 |
0.3619 |
|
Medicare supplemental |
2.8 |
2.9 |
−0.1 |
0.8945 |
|
Unknown line of business |
0.9 |
0.8 |
0.0 |
0.8464 |
There were no significant differences in the descriptive characteristics between cohorts.
Comorbid conditions
Overall, there were observed differences (p < 0.0001) in the CCI mean scores (DM cohort 0.82 ± 1.51 vs MC cohort 0.44 ± 1.19), the percentages of patients with CCI scores ≥ 1 (19.1% vs 9.7%), the number of ICD-9/-10 diagnoses (11.87 ± 10.28 vs 6.26 ± 7.11), and the number of prevalent AHRQ categories (8.66 ± 6.42 vs 4.88 ± 4.90).
The prevalence of pre-index healthcare conditions and associated PMPY costs and services used were higher in patients with DM compared with MCs. The largest differences in prevalence included the AHRQ categories “other nervous system disorders” (54.4% vs 10.2%), “other connective tissue disease” (49.4% vs 20.1%), and “other lower respiratory disease” (29.8% vs 14.6%). The 20 comorbid conditions with the largest cohort differences are shown in [Figure 2A].
Figure 2A: AHRQ categories with the largest between-group differences in (A) utilization, (B) PMPY per member per year costs, and (C) number of billed services
Abbreviations: AHRQ: Agency for Healthcare Research and Quality; DM: myotonic dystrophy; MC: matched control; PMPY: per-member-per-year
Pre-index prevalence was greater in patients with DM than in MCs in 143 of the 283 AHRQ categories. Pre-index PMPY costs differed in 22 AHRQ categories, 18 of which were higher in patients with DM. The 20 categories with the greatest PMPY cost differences are shown in [Figure 2B].
Figure 2b: AHRQ categories with the largest between-group differences in (A) utilization, (B) PMPY per member per year costs, and (C) number of billed services
Abbreviations: AHRQ: Agency for Healthcare Research and Quality; DM: myotonic dystrophy; MC: matched control; PMPY: per-member-per-year
The number of billed pre-index services differed in 50 AHRQ categories, 49 of which were higher in patients with DM. The 20 categories with the greatest differences in number of services are shown in [Figure 2C].
Figure 2C: AHRQ categories with the largest between-group differences in (A) utilization, (B) PMPY per member per year costs, and (C) number of billed services
Abbreviations: AHRQ: Agency for Healthcare Research and Quality; DM: myotonic dystrophy; MC: matched control; PMPY: per-member-per-year
Comparisons between the DM cohort and MCs of the 283 AHRQ categories are shown in [Supplementary Table 1].
Prescription medications
Comparison of claims for 88 ATC category 2 drugs, which are classified by the organ or system on which they act and their therapeutic properties, found 49 that had significantly higher use in the DM cohort. The 20 classes with the greatest differences are shown in [Figure 3A], and are led by systemic antibacterials (46.1% vs 35.5%), ophthalmologicals (36.3% vs 27.4%), and intestinal anti-inflammatory drugs (20.9% vs 13.4%).
Figure 3A: Anatomical Therapeutic Chemical category 2 drugs with the largest between-group differences in (A) utilization, (B) per member per year costs, and (C) number of fills.
Abbreviations: DM: myotonic dystrophy; Rx: prescription
Twenty categories had significant cost differences between cohorts, and the PMPY costs of 18 drug classes were higher in the DM cohort than in the MC cohort. The greatest differences [Figure 3B], were seen in diabetes drugs ($357 vs $227, p = 0.0169), antiepileptics ($122 vs $32, p = 0.0054), and drugs for obstructive-airway diseases ($219 vs $150, p = 0.0441).
Figure 3B: Anatomical Therapeutic Chemical category 2 drugs with the largest between-group differences in (A) utilization, (B) per member per year costs, and (C) number of fills.
Abbreviations: DM: myotonic dystrophy; Rx: prescription
Differences in prescription fills [Figure 3C], were significant in 42 of the 88 drug classes, and patients with DM had significantly more fills than MCs in 40 of the classes. The greatest PMPY differences in number of fills were for ophthalmologicals (1.35 vs 0.82), systemic antibacterials (1.39 vs 0.87), and psychoanaleptics (1.49 vs 1.04).
Figure 3C: Anatomical Therapeutic Chemical category 2 drugs with the largest between-group differences in (A) utilization, (B) per member per year costs, and (C) number of fills.
Abbreviations: DM: myotonic dystrophy; Rx: prescription
Differences in all three metrics in ATC class 2 drugs are in line with those found in class 3 and 4 drugs, which are shown in [Supplementary Tables 2] [Supplementary Table 3].
Supplementary Table 3: Comparisons between the DM cohort and MCs of ATC4 class categories
| AHRQ Category Number | AHRQ Category | Percent of All DM Members | Percent of All Non-DM Members | Prevalence Comparisons | Allowed Amount per DM Member (PMPY) | Allowed Amount per Non-DM Member (PMPY) | Cost Comparison | Services per DM Member (PMPY) | Services per Non-DM Member (PMPY) | Services Comparison | ||||||||||
| Difference | Relative Difference | P-Value | Mean | Standard Deviation | Mean | Standard Deviation | Difference | P-Value | Mean | Standard Deviation | Mean | Standard Deviation | Difference | P-Value | ||||||
| (chi-square test) | (t-test) | (t-test) | ||||||||||||||||||
| 95 | Other nervous system disorders | 54.40% | 10.20% | 44.20% | 431% | <0.0001 | $2,335 | $31,763 | $57 | $809 | $2,278 | 0 | 7 | 28 | 0.3 | 2.6 | 6.7 | <0.0001 | ||
| 211 | Other connective tissue disease | 49.40% | 20.10% | 29.30% | 146% | <0.0001 | $556 | $2,108 | $105 | $1,130 | $451 | <0.0001 | 3.5 | 9.6 | 0.8 | 4.5 | 2.7 | <0.0001 | ||
| 259 | Residual codes; unclassified | 44.60% | 24.10% | 20.50% | 85% | <0.0001 | $332 | $1,478 | $88 | $628 | $244 | <0.0001 | 2 | 7.5 | 0.7 | 4.2 | 1.3 | <0.0001 | ||
| 133 | Other lower respiratory disease | 29.80% | 14.60% | 15.20% | 104% | <0.0001 | $169 | $930 | $59 | $606 | $109 | <0.0001 | 1.3 | 4.8 | 0.5 | 2.9 | 0.8 | <0.0001 | ||
| 252 | Malaise and fatigue | 24.10% | 9.50% | 14.60% | 153% | <0.0001 | $130 | $1,388 | $19 | $452 | $112 | 0 | 1 | 4.5 | 0.3 | 1.8 | 0.7 | <0.0001 | ||
| 155 | Other gastrointestinal disorders | 23.60% | 9.40% | 14.20% | 152% | <0.0001 | $401 | $4,091 | $43 | $531 | $358 | 0 | 1.7 | 15 | 0.3 | 1.9 | 1.4 | 0 | ||
| 257 | Other aftercare | 24.50% | 13.50% | 11.00% | 82% | <0.0001 | $165 | $2,713 | $53 | $1,133 | $112 | 0.1 | 1.2 | 9.2 | 0.5 | 4.6 | 0.7 | 0 | ||
| 106 | Cardiac dysrhythmias | 17.40% | 6.50% | 10.90% | 168% | <0.0001 | $233 | $2,225 | $75 | $1,699 | $157 | 0 | 1 | 4.8 | 0.4 | 4.3 | 0.6 | <0.0001 | ||
| 205 | Spondylosis; intervertebral disc disorders; other back problems | 27.70% | 17.00% | 10.60% | 62% | <0.0001 | $361 | $2,863 | $204 | $2,222 | $157 | 0 | 2.4 | 10 | 1.7 | 9.4 | 0.8 | 0 | ||
| 86 | Cataract | 14.70% | 4.80% | 9.90% | 205% | <0.0001 | $169 | $1,199 | $32 | $453 | $137 | <0.0001 | 0.5 | 2.9 | 0.1 | 1.2 | 0.4 | <0.0001 | ||
| 91 | Other eye disorders | 16.10% | 7.90% | 8.20% | 104% | <0.0001 | $53 | $462 | $18 | $280 | $35 | 0 | 0.3 | 1.4 | 0.1 | 0.8 | 0.2 | <0.0001 | ||
| 204 | Other non-traumatic joint disorders | 24.10% | 15.90% | 8.20% | 51% | <0.0001 | $131 | $1,021 | $74 | $564 | $57 | 0 | 1.5 | 7.8 | 0.8 | 4.4 | 0.7 | 0 | ||
| 258 | Other screening for suspected conditions (not mental disorders or infectious disease) | 37.40% | 29.30% | 8.10% | 28% | <0.0001 | $149 | $551 | $111 | $474 | $38 | 0 | 1.2 | 3.2 | 0.9 | 2.3 | 0.3 | 0 | ||
| 58 | Other nutritional; endocrine; and metabolic disorders | 23.50% | 15.40% | 8.10% | 53% | <0.0001 | $376 | $9,954 | $39 | $876 | $338 | 0.2 | 0.6 | 4.7 | 0.2 | 2.2 | 0.4 | 0 | ||
| 81 | Other hereditary and degenerative nervous system conditions | 8.90% | 1.20% | 7.60% | 628% | <0.0001 | $246 | $4,106 | $5 | $205 | $241 | 0 | 1 | 12 | 0.1 | 2.6 | 0.9 | 0 | ||
| 52 | Nutritional deficiencies | 14.50% | 6.80% | 7.60% | 112% | <0.0001 | $12 | $110 | $4 | $50 | $8 | 0 | 0.3 | 1.9 | 0.1 | 1.1 | 0.2 | 0 | ||
| 256 | Medical examination/evaluation | 45.20% | 37.70% | 7.50% | 20% | <0.0001 | $114 | $285 | $92 | $185 | $22 | 0 | 1.9 | 3.7 | 1.7 | 3.8 | 0.2 | 0.1 | ||
| 244 | Other injuries and conditions due to external causes | 12.90% | 6.10% | 6.80% | 111% | <0.0001 | $68 | $684 | $19 | $300 | $48 | 0 | 0.4 | 2.6 | 0.1 | 1.1 | 0.3 | <0.0001 | ||
| 151 | Other liver diseases | 10.20% | 3.50% | 6.70% | 194% | <0.0001 | $189 | $5,435 | $11 | $183 | $178 | 0.2 | 0.5 | 4.3 | 0.1 | 1.8 | 0.4 | 0 | ||
| 53 | Disorders of lipid metabolism | 28.60% | 21.80% | 6.70% | 31% | <0.0001 | $24 | $95 | $20 | $158 | $5 | 0.1 | 0.8 | 2.6 | 0.5 | 2.4 | 0.2 | 0 | ||
| 163 | Genitourinary symptoms and ill-defined conditions | 15.30% | 8.90% | 6.50% | 73% | <0.0001 | $52 | $414 | $24 | $345 | $28 | 0 | 0.6 | 3.3 | 0.3 | 1.9 | 0.3 | 0 | ||
| 48 | Thyroid disorders | 15.70% | 9.20% | 6.50% | 70% | <0.0001 | $68 | $613 | $20 | $209 | $48 | 0 | 0.8 | 3.7 | 0.4 | 2.6 | 0.4 | <0.0001 | ||
| 10 | Immunizations and screening for infectious disease | 33.20% | 26.80% | 6.40% | 24% | <0.0001 | $33 | $227 | $23 | $98 | $11 | 0.1 | 0.8 | 5.8 | 0.6 | 1.7 | 0.3 | 0.1 | ||
| 200 | Other skin disorders | 22.90% | 16.60% | 6.30% | 38% | <0.0001 | $57 | $414 | $32 | $169 | $24 | 0 | 0.5 | 1.8 | 0.3 | 1.6 | 0.2 | 0 | ||
| 89 | Blindness and vision defects | 13.50% | 7.30% | 6.30% | 86% | <0.0001 | $13 | $99 | $8 | $121 | $4 | 0.1 | 0.2 | 0.8 | 0.1 | 0.7 | 0.1 | 0 | ||
| 138 | Esophageal disorders | 14.20% | 8.00% | 6.20% | 78% | <0.0001 | $43 | $380 | $22 | $393 | $21 | 0 | 0.2 | 1.3 | 0.1 | 1.2 | 0.1 | 0 | ||
| 55 | Fluid and electrolyte disorders | 9.20% | 3.00% | 6.20% | 210% | <0.0001 | $46 | $653 | $7 | $185 | $39 | 0 | 0.2 | 2.3 | 0.1 | 1.3 | 0.2 | 0 | ||
| 117 | Other circulatory disease | 11.90% | 5.70% | 6.20% | 108% | <0.0001 | $57 | $885 | $9 | $139 | $48 | 0 | 0.3 | 4.3 | 0.1 | 0.7 | 0.3 | 0 | ||
| 59 | Deficiency and other anemia | 11.00% | 5.00% | 6.00% | 121% | <0.0001 | $39 | $417 | $121 | $8,084 | −$82 | 0.4 | 0.5 | 2.8 | 0.4 | 8.6 | 0.1 | 0.3 | ||
| 251 | Abdominal pain | 15.90% | 10.00% | 5.90% | 59% | <0.0001 | $152 | $902 | $84 | $743 | $68 | 0 | 1.1 | 5.3 | 0.6 | 4 | 0.5 | 0 | ||
| 47 | Other and unspecified benign neoplasm | 16.20% | 10.30% | 5.90% | 57% | <0.0001 | $215 | $3,025 | $60 | $929 | $156 | 0 | 0.5 | 2.4 | 0.2 | 1.3 | 0.3 | <0.0001 | ||
| 105 | Conduction disorders | 7.10% | 1.30% | 5.80% | 445% | <0.0001 | $213 | $4,188 | $10 | $443 | $202 | 0 | 0.3 | 2.9 | 0 | 0.6 | 0.3 | 0 | ||
| 97 | Peri-; endo-; and myocarditis; cardiomyopathy (except that caused by tuberculosis or sexually transmitted disease) | 6.40% | 1.10% | 5.30% | 507% | <0.0001 | $107 | $2,111 | $13 | $501 | $94 | 0.1 | 0.4 | 4.8 | 0 | 1 | 0.4 | 0 | ||
| 126 | Other upper respiratory infections | 25.90% | 20.80% | 5.10% | 25% | <0.0001 | $71 | $462 | $78 | $2,203 | −$7 | 0.8 | 0.7 | 2.6 | 0.6 | 3.1 | 0.2 | 0 | ||
| 134 | Other upper respiratory disease | 15.90% | 11.10% | 4.80% | 43% | <0.0001 | $87 | $1,072 | $37 | $417 | $50 | 0.1 | 0.5 | 3.2 | 0.3 | 2.9 | 0.1 | 0.1 | ||
| 94 | Other ear and sense organ disorders | 10.90% | 6.20% | 4.70% | 76% | <0.0001 | $78 | $1,273 | $14 | $227 | $64 | 0 | 0.3 | 2.1 | 0.1 | 0.7 | 0.2 | <0.0001 | ||
| 250 | Nausea and vomiting | 9.20% | 4.50% | 4.70% | 104% | <0.0001 | $36 | $524 | $13 | $243 | $23 | 0.1 | 0.2 | 1.9 | 0.1 | 1.8 | 0.1 | 0 | ||
| 130 | Pleurisy; pneumothorax; pulmonary collapse | 6.30% | 1.60% | 4.70% | 296% | <0.0001 | $25 | $530 | $6 | $203 | $19 | 0.1 | 0.3 | 2.4 | 0.1 | 1.3 | 0.2 | 0 | ||
| 131 | Respiratory failure; insufficiency; arrest (adult) | 5.40% | 0.80% | 4.70% | 597% | <0.0001 | $1,953 | $23,168 | $50 | $2,800 | $1,903 | 0 | 1.7 | 15 | 0.1 | 2.4 | 1.7 | <0.0001 | ||
| 209 | Other acquired deformities | 6.10% | 1.50% | 4.60% | 312% | <0.0001 | $90 | $2,769 | $10 | $592 | $80 | 0.2 | 0.1 | 1 | 0 | 1.3 | 0.1 | 0.1 | ||
| 102 | Nonspecific chest pain | 11.40% | 6.80% | 4.60% | 67% | <0.0001 | $122 | $968 | $83 | $770 | $39 | 0.1 | 0.9 | 5.1 | 0.5 | 4.3 | 0.3 | 0 | ||
| 49 | Diabetes mellitus without complication | 16.20% | 11.70% | 4.50% | 39% | <0.0001 | $81 | $1,035 | $37 | $401 | $44 | 0.1 | 1.3 | 12 | 0.6 | 3.2 | 0.7 | 0 | ||
| 159 | Urinary tract infections | 10.30% | 5.80% | 4.50% | 77% | <0.0001 | $61 | $855 | $27 | $508 | $34 | 0.1 | 0.6 | 3.7 | 0.3 | 1.8 | 0.3 | 0 | ||
| 122 | Pneumonia (except that caused by tuberculosis or sexually transmitted disease) | 6.30% | 1.80% | 4.50% | 243% | <0.0001 | $329 | $4,295 | $59 | $2,219 | $270 | 0 | 0.8 | 7.1 | 0.2 | 2.6 | 0.7 | 0 | ||
| 254 | Rehabilitation care; fitting of prostheses; and adjustment of devices | 5.80% | 1.50% | 4.40% | 296% | <0.0001 | $276 | $6,319 | $56 | $1,090 | $221 | 0.2 | 0.7 | 6.1 | 0.1 | 1.9 | 0.5 | 0 | ||
| 96 | Heart valve disorders | 7.10% | 3.00% | 4.10% | 140% | <0.0001 | $102 | $3,142 | $19 | $806 | $83 | 0.3 | 0.1 | 1.6 | 0.1 | 1.3 | 0.1 | 0.1 | ||
| 657 | Mood disorders | 13.20% | 9.10% | 4.10% | 45% | <0.0001 | $134 | $2,155 | $61 | $860 | $73 | 0.2 | 0.8 | 6.1 | 0.5 | 3.7 | 0.3 | 0.1 | ||
| 44 | Neoplasms of unspecified nature or uncertain behavior | 8.60% | 4.70% | 3.90% | 84% | <0.0001 | $31 | $233 | $30 | $764 | $0 | 1 | 0.2 | 1.5 | 0.1 | 1.6 | 0.1 | 0.1 | ||
| 51 | Other endocrine disorders | 6.90% | 3.00% | 3.90% | 131% | <0.0001 | $66 | $990 | $17 | $445 | $49 | 0 | 0.5 | 4.2 | 0.2 | 2 | 0.3 | 0 | ||
| 93 | Conditions associated with dizziness or vertigo | 7.40% | 3.50% | 3.80% | 108% | <0.0001 | $53 | $502 | $11 | $194 | $42 | 0 | 0.3 | 2.2 | 0.1 | 1 | 0.2 | 0 | ||
| 84 | Headache; including migraine | 10.60% | 6.80% | 3.80% | 57% | <0.0001 | $37 | $271 | $34 | $459 | $3 | 0.7 | 0.3 | 1.9 | 0.2 | 2.6 | 0 | 0.5 | ||
| 212 | Other bone disease and musculoskeletal deformities | 12.10% | 8.40% | 3.70% | 45% | <0.0001 | $53 | $500 | $35 | $728 | $18 | 0.2 | 0.8 | 4.4 | 0.5 | 4.5 | 0.2 | 0.1 | ||
| 90 | Inflammation; infection of eye (except that caused by tuberculosis or sexually transmitted disease) | 8.50% | 4.80% | 3.70% | 76% | <0.0001 | $19 | $217 | $7 | $54 | $13 | 0 | 0.2 | 0.9 | 0.1 | 0.6 | 0.1 | 0 | ||
| ### | External cause codes: Fall | 5.10% | 1.60% | 3.50% | 220% | <0.0001 | $0 | $2 | $0 | $0 | $0 | 0.3 | 0 | 0.1 | 0 | 0 | 0 | 0.3 | ||
| 246 | Fever of unknown origin | 6.80% | 3.30% | 3.50% | 108% | <0.0001 | $39 | $764 | $5 | $94 | $35 | 0.1 | 0.2 | 1.5 | 0.1 | 0.8 | 0.1 | 0 | ||
| 239 | Superficial injury; contusion | 7.80% | 4.40% | 3.40% | 78% | <0.0001 | $43 | $397 | $19 | $425 | $24 | 0 | 0.3 | 1.7 | 0.1 | 0.8 | 0.2 | 0 | ||
| 197 | Skin and subcutaneous tissue infections | 7.60% | 4.20% | 3.40% | 80% | <0.0001 | $62 | $1,063 | $29 | $566 | $33 | 0.2 | 0.3 | 2.7 | 0.2 | 2.5 | 0.2 | 0 | ||
| 108 | Congestive heart failure; nonhypertensive | 4.80% | 1.50% | 3.40% | 228% | <0.0001 | $800 | $24,743 | $14 | $344 | $785 | 0.2 | 0.4 | 4.4 | 0.1 | 1.6 | 0.3 | 0 | ||
| 654 | Developmental disorders | 3.70% | 0.40% | 3.30% | 800% | <0.0001 | $57 | $736 | $2 | $68 | $55 | 0 | 0.3 | 3.2 | 0 | 1.2 | 0.2 | 0 | ||
| 101 | Coronary atherosclerosis and other heart disease | 7.10% | 3.90% | 3.20% | 83% | <0.0001 | $80 | $1,447 | $76 | $1,930 | $3 | 0.9 | 0.3 | 1.9 | 0.2 | 2.4 | 0.1 | 0.2 | ||
| 127 | Chronic obstructive pulmonary disease and bronchiectasis | 7.60% | 4.50% | 3.10% | 69% | <0.0001 | $38 | $387 | $34 | $728 | $4 | 0.8 | 0.4 | 3 | 0.3 | 4.3 | 0.1 | 0.4 | ||
| 217 | Other congenital anomalies | 4.30% | 1.20% | 3.10% | 264% | <0.0001 | $188 | $3,717 | $10 | $523 | $178 | 0 | 0.2 | 3.2 | 0 | 1.3 | 0.2 | 0 | ||
| 104 | Other and ill-defined heart disease | 4.50% | 1.40% | 3.10% | 219% | <0.0001 | $14 | $192 | $1 | $50 | $13 | 0 | 0.1 | 1.3 | 0 | 0.3 | 0.1 | 0 | ||
| 87 | Retinal detachments; defects; vascular occlusion; and retinopathy | 5.80% | 2.80% | 3.00% | 106% | <0.0001 | $52 | $685 | $26 | $667 | $27 | 0.1 | 0.2 | 1.8 | 0.1 | 1.7 | 0.1 | 0 | ||
| 62 | Coagulation and hemorrhagic disorders | 4.40% | 1.40% | 3.00% | 210% | <0.0001 | $6 | $68 | $199 | $13,064 | −$192 | 0.2 | 0.1 | 1.2 | 0.1 | 3.6 | 0 | 0.9 | ||
| 4 | Mycoses | 7.10% | 4.30% | 2.90% | 67% | <0.0001 | $7 | $87 | $5 | $83 | $2 | 0.4 | 0.1 | 0.9 | 0.1 | 0.6 | 0 | 0.1 | ||
| 253 | Allergic reactions | 11.70% | 8.90% | 2.80% | 31% | 0.0003 | $12 | $89 | $17 | $396 | −$4 | 0.4 | 0.2 | 1 | 0.1 | 0.9 | 0 | 0.2 | ||
| 82 | Paralysis | 3.10% | 0.30% | 2.70% | 797% | <0.0001 | $38 | $548 | $1 | $25 | $38 | 0 | 0.1 | 1.9 | 0 | 0.2 | 0.1 | 0 | ||
| 232 | Sprains and strains | 9.60% | 7.10% | 2.60% | 36% | 0.0003 | $44 | $253 | $65 | $1,329 | −$21 | 0.2 | 0.5 | 3.4 | 0.4 | 3.8 | 0.1 | 0.3 | ||
| 50 | Diabetes mellitus with complications | 6.50% | 4.20% | 2.30% | 56% | <0.0001 | $65 | $573 | $92 | $3,684 | −$27 | 0.5 | 0.8 | 5.9 | 0.3 | 3 | 0.4 | 0 | ||
| 208 | Acquired foot deformities | 4.10% | 1.80% | 2.30% | 132% | <0.0001 | $32 | $489 | $16 | $579 | $17 | 0.2 | 0.2 | 2.5 | 0.1 | 1.2 | 0.1 | 0.1 | ||
| 238 | Complications of surgical procedures or medical care | 4.30% | 2.10% | 2.20% | 109% | <0.0001 | $51 | $774 | $62 | $1,470 | −$11 | 0.7 | 0.2 | 2.2 | 0.1 | 1.7 | 0.1 | 0.1 | ||
| 80 | Multiple sclerosis | 2.50% | 0.30% | 2.20% | 727% | <0.0001 | $37 | $589 | $10 | $368 | $26 | 0.1 | 0.2 | 2.2 | 0.1 | 1.7 | 0.1 | 0.1 | ||
| 2 | Septicemia (except in labor) | 2.70% | 0.40% | 2.20% | 525% | <0.0001 | $575 | $8,619 | $47 | $1,439 | $528 | 0 | 0.4 | 3.7 | 0.1 | 1.4 | 0.3 | 0 | ||
| 63 | Diseases of white blood cells | 3.60% | 1.40% | 2.20% | 154% | <0.0001 | $38 | $930 | $17 | $828 | $21 | 0.4 | 0.2 | 2.1 | 0.1 | 1.9 | 0.1 | 0 | ||
| 651 | Anxiety disorders | 11.30% | 9.10% | 2.10% | 24% | 0.0059 | $35 | $350 | $22 | $244 | $12 | 0.2 | 0.3 | 2.1 | 0.2 | 2.1 | 0 | 0.4 | ||
| 199 | Chronic ulcer of skin | 2.80% | 0.60% | 2.10% | 327% | <0.0001 | $40 | $884 | $4 | $137 | $36 | 0.1 | 0.3 | 4.4 | 0 | 0.9 | 0.2 | 0 | ||
| 245 | Syncope | 3.50% | 1.40% | 2.10% | 148% | <0.0001 | $25 | $268 | $18 | $401 | $7 | 0.3 | 0.2 | 1.5 | 0.1 | 1.7 | 0 | 0.3 | ||
| 255 | Administrative/social admission | 10.80% | 8.80% | 2.00% | 23% | 0.0076 | $19 | $123 | $14 | $88 | $5 | 0.1 | 0.3 | 2.4 | 0.2 | 1.3 | 0.1 | 0.1 | ||
| 210 | Systemic lupus erythematosus and connective tissue disorders | 2.50% | 0.50% | 1.90% | 367% | <0.0001 | $29 | $757 | $2 | $39 | $27 | 0.1 | 0.2 | 1.8 | 0 | 0.7 | 0.1 | 0 | ||
| 3 | Bacterial infection; unspecified site | 3.40% | 1.40% | 1.90% | 134% | <0.0001 | $35 | $1,288 | $1 | $53 | $34 | 0.3 | 0.1 | 1.1 | 0 | 0.5 | 0 | 0.1 | ||
| 663 | Screening and history of mental health and substance abuse codes | 7.20% | 5.30% | 1.90% | 36% | 0.0021 | $1 | $11 | $1 | $73 | −$1 | 0.4 | 0 | 0.2 | 0 | 0.3 | 0 | 0.5 | ||
| 114 | Peripheral and visceral atherosclerosis | 3.30% | 1.50% | 1.90% | 128% | <0.0001 | $8 | $116 | $19 | $1,014 | −$10 | 0.4 | 0.1 | 0.6 | 0 | 0.7 | 0 | 0 | ||
| 128 | Asthma | 7.40% | 5.60% | 1.80% | 33% | 0.0036 | $28 | $387 | $19 | $609 | $9 | 0.4 | 0.3 | 2.4 | 0.1 | 1.7 | 0.1 | 0 | ||
| 118 | Phlebitis; thrombophlebitis and thromboembolism | 2.70% | 1.00% | 1.70% | 180% | <0.0001 | $7 | $132 | $4 | $116 | $3 | 0.3 | 0.2 | 1.9 | 0.1 | 1 | 0.1 | 0 | ||
| 149 | Biliary tract disease | 3.00% | 1.30% | 1.70% | 130% | <0.0001 | $60 | $967 | $75 | $1,890 | −$15 | 0.6 | 0.2 | 2.6 | 0.2 | 2.7 | 0 | 0.6 | ||
| 125 | Acute bronchitis | 6.70% | 5.10% | 1.70% | 33% | 0.0051 | $29 | $453 | $19 | $959 | $10 | 0.5 | 0.2 | 1.1 | 0.1 | 0.7 | 0.1 | 0 | ||
| 153 | Gastrointestinal hemorrhage | 3.20% | 1.50% | 1.70% | 108% | <0.0001 | $114 | $3,777 | $15 | $345 | $99 | 0.3 | 0.1 | 1.9 | 0.1 | 0.9 | 0.1 | 0.1 | ||
| 230 | Fracture of lower limb | 3.00% | 1.30% | 1.60% | 125% | <0.0001 | $93 | $1,350 | $36 | $1,162 | $58 | 0.1 | 0.5 | 6.6 | 0.1 | 2.9 | 0.3 | 0 | ||
| 198 | Other inflammatory condition of skin | 5.70% | 4.00% | 1.60% | 40% | 0.0028 | $7 | $50 | $13 | $492 | −$7 | 0.2 | 0.1 | 0.7 | 0.1 | 1.4 | 0 | 0.8 | ||
| 655 | Disorders usually diagnosed in infancy childhood or adolescence | 1.90% | 0.30% | 1.60% | 469% | <0.0001 | $31 | $931 | $20 | $884 | $12 | 0.6 | 0.3 | 7.2 | 0.1 | 5.9 | 0.2 | 0.4 | ||
| 103 | Pulmonary heart disease | 2.40% | 0.80% | 1.60% | 197% | <0.0001 | $11 | $159 | $17 | $529 | −$6 | 0.4 | 0.2 | 2.2 | 0.1 | 1.5 | 0.1 | 0.1 | ||
| 83 | Epilepsy; convulsions | 2.70% | 1.10% | 1.60% | 153% | <0.0001 | $160 | $3,371 | $18 | $612 | $143 | 0.1 | 0.4 | 5.7 | 0.1 | 1.4 | 0.3 | 0 | ||
| 235 | Open wounds of head; neck; and trunk | 2.80% | 1.20% | 1.60% | 135% | <0.0001 | $31 | $506 | $11 | $249 | $20 | 0.1 | 0.1 | 1.3 | 0 | 0.7 | 0.1 | 0 | ||
| 175 | Other female genital disorders | 5.90% | 4.30% | 1.60% | 36% | 0.0048 | $31 | $529 | $26 | $454 | $5 | 0.7 | 0.2 | 1.3 | 0.2 | 1.6 | 0 | 0.7 | ||
| 57 | Immunity disorders | 2.00% | 0.50% | 1.50% | 336% | <0.0001 | $91 | $2,630 | $42 | $1,901 | $49 | 0.5 | 0.3 | 3.4 | 0.1 | 1.6 | 0.2 | 0 | ||
| 7 | Viral infection | 6.80% | 5.30% | 1.50% | 29% | 0.0119 | $29 | $533 | $9 | $78 | $21 | 0.1 | 0.2 | 1.9 | 0.1 | 0.9 | 0.1 | 0 | ||
| 92 | Otitis media and related conditions | 6.30% | 4.80% | 1.50% | 31% | 0.0096 | $18 | $206 | $10 | $139 | $8 | 0.1 | 0.2 | 1.2 | 0.1 | 0.6 | 0.1 | 0 | ||
| 129 | Aspiration pneumonitis; food/vomitus | 1.60% | 0.10% | 1.50% | 1400% | <0.0001 | $239 | $3,837 | $5 | $326 | $234 | 0 | 0.2 | 2.7 | 0 | 0.5 | 0.2 | 0 | ||
| 64 | Other hematologic conditions | 2.00% | 0.50% | 1.50% | 270% | <0.0001 | $3 | $38 | $1 | $26 | $2 | 0.1 | 0.1 | 0.8 | 0 | 0.3 | 0 | 0 | ||
| 650 | Adjustment disorders | 3.70% | 2.20% | 1.40% | 65% | 0.0005 | $23 | $254 | $13 | $170 | $10 | 0.1 | 0.2 | 1.6 | 0.1 | 1.8 | 0 | 0.3 | ||
| 23 | Other non-epithelial cancer of skin | 3.40% | 2.00% | 1.40% | 68% | 0.0005 | $38 | $426 | $18 | $449 | $21 | 0.1 | 0.2 | 1.7 | 0.1 | 1.2 | 0.1 | 0 | ||
| 670 | Miscellaneous mental health disorders | 2.90% | 1.50% | 1.40% | 88% | 0.0001 | $2 | $31 | $11 | $528 | −$9 | 0.1 | 0 | 0.3 | 0 | 1.3 | 0 | 0.3 | ||
| 141 | Other disorders of stomach and duodenum | 2.50% | 1.20% | 1.30% | 105% | <0.0001 | $12 | $202 | $10 | $668 | $2 | 0.8 | 0.1 | 0.7 | 0 | 1.2 | 0 | 0.7 | ||
| 162 | Other diseases of bladder and urethra | 2.20% | 0.90% | 1.30% | 143% | <0.0001 | $17 | $451 | $10 | $750 | $7 | 0.6 | 0.1 | 1.6 | 0 | 0.7 | 0.1 | 0.2 | ||
| 135 | Intestinal infection | 2.10% | 0.80% | 1.30% | 161% | <0.0001 | $72 | $1,363 | $5 | $144 | $67 | 0 | 0.1 | 1.7 | 0 | 0.7 | 0.1 | 0.1 | ||
| 202 | Rheumatoid arthritis and related disease | 2.20% | 1.00% | 1.30% | 132% | <0.0001 | $83 | $1,920 | $31 | $1,301 | $52 | 0.3 | 0.1 | 2.1 | 0.1 | 2.4 | 0 | 0.8 | ||
| 157 | Acute and unspecified renal failure | 2.10% | 0.80% | 1.20% | 146% | <0.0001 | $52 | $1,034 | $15 | $421 | $37 | 0.1 | 0.1 | 1.5 | 0.1 | 1.3 | 0 | 0.2 | ||
| 206 | Osteoporosis | 2.70% | 1.50% | 1.20% | 83% | 0.0003 | $18 | $403 | $6 | $120 | $12 | 0.2 | 0.1 | 2 | 0 | 0.4 | 0.1 | 0.1 | ||
| 140 | Gastritis and duodenitis | 3.40% | 2.20% | 1.20% | 55% | 0.0029 | $26 | $368 | $23 | $506 | $3 | 0.8 | 0.1 | 1.2 | 0.1 | 2 | 0 | 0.7 | ||
| 88 | Glaucoma | 4.10% | 2.90% | 1.20% | 41% | 0.0102 | $14 | $130 | $10 | $93 | $4 | 0.3 | 0.1 | 0.9 | 0.1 | 0.8 | 0 | 0.2 | ||
| 171 | Menstrual disorders | 4.80% | 3.60% | 1.20% | 32% | 0.0218 | $48 | $740 | $22 | $381 | $26 | 0.2 | 0.2 | 2 | 0.1 | 1.3 | 0.1 | 0.1 | ||
| 136 | Disorders of teeth and jaw | 2.60% | 1.40% | 1.20% | 80% | 0.0006 | $10 | $167 | $8 | $232 | $2 | 0.7 | 0.1 | 0.8 | 0 | 0.5 | 0 | 0.1 | ||
| 231 | Other fractures | 1.90% | 0.80% | 1.10% | 132% | <0.0001 | $34 | $852 | $21 | $651 | $13 | 0.6 | 0.1 | 2 | 0.1 | 1.5 | 0 | 0.6 | ||
| 100 | Acute myocardial infarction | 1.50% | 0.40% | 1.10% | 279% | <0.0001 | $233 | $7,243 | $55 | $1,862 | $178 | 0.3 | 0.3 | 7.5 | 0.1 | 1.3 | 0.2 | 0.2 | ||
| 164 | Hyperplasia of prostate | 3.50% | 2.50% | 1.10% | 43% | 0.013 | $4 | $46 | $6 | $131 | −$1 | 0.4 | 0.1 | 0.7 | 0.1 | 0.8 | 0 | 0.8 | ||
| 85 | Coma; stupor; and brain damage | 1.60% | 0.50% | 1.10% | 193% | <0.0001 | $5 | $75 | $2 | $65 | $3 | 0.1 | 0 | 0.3 | 0 | 0.5 | 0 | 0.2 | ||
| 120 | Hemorrhoids | 3.50% | 2.40% | 1.10% | 43% | 0.0132 | $42 | $1,426 | $11 | $322 | $32 | 0.4 | 0.1 | 1.3 | 0 | 0.7 | 0 | 0.4 | ||
| 166 | Other male genital disorders | 3.30% | 2.30% | 1.00% | 45% | 0.0125 | $34 | $1,222 | $8 | $234 | $27 | 0.4 | 0.1 | 0.9 | 0 | 0.7 | 0 | 0.7 | ||
| 160 | Calculus of urinary tract | 2.50% | 1.50% | 1.00% | 67% | 0.0031 | $49 | $720 | $43 | $888 | $6 | 0.8 | 0.3 | 3.8 | 0.2 | 2.7 | 0.1 | 0.2 | ||
| 652 | Attention-deficit conduct and disruptive behavior disorders | 3.20% | 2.30% | 1.00% | 43% | 0.0168 | $6 | $67 | $5 | $78 | $1 | 0.5 | 0.1 | 0.6 | 0.1 | 0.9 | 0 | 0.9 | ||
| 161 | Other diseases of kidney and ureters | 3.10% | 2.20% | 1.00% | 44% | 0.0173 | $27 | $496 | $26 | $737 | $1 | 0.9 | 0.1 | 1.5 | 0.1 | 1.3 | 0 | 0.3 | ||
| 172 | Ovarian cyst | 2.10% | 1.10% | 0.90% | 82% | 0.0019 | $23 | $465 | $6 | $159 | $17 | 0.1 | 0.1 | 1 | 0 | 0.6 | 0 | 0.1 | ||
| 237 | Complication of device; implant or graft | 1.90% | 1.00% | 0.90% | 98% | 0.0008 | $59 | $1,338 | $53 | $1,609 | $7 | 0.9 | 0.1 | 1.5 | 0.1 | 2.6 | 0 | 0.7 | ||
| ### | External cause codes: Unspecified | 1.80% | 0.90% | 0.90% | 101% | 0.0007 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 121 | Other diseases of veins and lymphatics | 2.10% | 1.20% | 0.90% | 79% | 0.0027 | $18 | $295 | $11 | $304 | $7 | 0.4 | 0.1 | 2.3 | 0.1 | 1 | 0.1 | 0.2 | ||
| 154 | Noninfectious gastroenteritis | 2.40% | 1.50% | 0.90% | 58% | 0.0097 | $17 | $219 | $12 | $239 | $5 | 0.4 | 0.2 | 1.6 | 0.1 | 1 | 0.1 | 0 | ||
| 229 | Fracture of upper limb | 1.80% | 0.90% | 0.90% | 94% | 0.0014 | $118 | $2,296 | $31 | $889 | $87 | 0.1 | 0.3 | 3.7 | 0.1 | 1.6 | 0.2 | 0.1 | ||
| 145 | Intestinal obstruction without hernia | 1.40% | 0.60% | 0.90% | 155% | 0.0001 | $220 | $5,417 | $24 | $910 | $197 | 0.1 | 0.2 | 3.3 | 0.1 | 1.6 | 0.1 | 0.1 | ||
| 109 | Acute cerebrovascular disease | 1.40% | 0.60% | 0.80% | 145% | 0.0002 | $55 | $1,264 | $16 | $944 | $39 | 0.2 | 0.1 | 2 | 0 | 1.1 | 0.1 | 0.2 | ||
| 249 | Shock | 0.90% | 0.10% | 0.80% | 700% | <0.0001 | $3 | $78 | $0 | $11 | $3 | 0.1 | 0 | 0.3 | 0 | 0.1 | 0 | 0.1 | ||
| 111 | Other and ill-defined cerebrovascular disease | 1.20% | 0.40% | 0.80% | 194% | 0.0001 | $8 | $210 | $1 | $33 | $7 | 0.1 | 0 | 0.7 | 0 | 0.1 | 0 | 0.2 | ||
| 158 | Chronic kidney disease | 2.30% | 1.50% | 0.80% | 51% | 0.0217 | $100 | $2,846 | $49 | $1,696 | $51 | 0.5 | 0.6 | 16 | 0.5 | 15 | 0.1 | 0.8 | ||
| 8 | Other infections; including parasitic | 1.70% | 0.90% | 0.80% | 81% | 0.0051 | $2 | $23 | $3 | $110 | −$1 | 0.4 | 0 | 0.3 | 0 | 0.9 | 0 | 0.6 | ||
| 168 | Inflammatory diseases of female pelvic organs | 3.30% | 2.60% | 0.80% | 30% | 0.0786 | $6 | $60 | $12 | $454 | −$6 | 0.3 | 0.1 | 0.8 | 0.1 | 1.2 | 0 | 0.8 | ||
| 653 | Delirium dementia and amnestic and other cognitive disorders | 1.70% | 0.90% | 0.70% | 79% | 0.0068 | $6 | $107 | $15 | $758 | −$9 | 0.3 | 0 | 0.7 | 0.1 | 4.3 | 0 | 0.3 | ||
| 216 | Nervous system congenital anomalies | 0.80% | 0.00% | 0.70% | 1525% | <0.0001 | $31 | $732 | $1 | $57 | $31 | 0.1 | 0.1 | 1.2 | 0 | 0.2 | 0.1 | 0.1 | ||
| 137 | Diseases of mouth; excluding dental | 1.80% | 1.10% | 0.70% | 63% | 0.0181 | $4 | $87 | $3 | $77 | $2 | 0.4 | 0 | 0.4 | 0 | 0.3 | 0 | 0.5 | ||
| 60 | Acute posthemorrhagic anemia | 1.10% | 0.40% | 0.70% | 157% | 0.0005 | $0 | $9 | $6 | $268 | −$6 | 0 | 0 | 0 | 0 | 0.4 | 0 | 0 | ||
| 233 | Intracranial injury | 1.10% | 0.50% | 0.70% | 144% | 0.001 | $74 | $2,600 | $8 | $278 | $66 | 0.3 | 0.1 | 3.3 | 0 | 0.7 | 0.1 | 0.2 | ||
| 46 | Benign neoplasm of uterus | 1.80% | 1.10% | 0.60% | 56% | 0.0304 | $40 | $878 | $18 | $600 | $22 | 0.3 | 0.1 | 1.6 | 0 | 0.9 | 0.1 | 0.2 | ||
| ### | External cause codes: Place of occurrence | 1.20% | 0.60% | 0.60% | 102% | 0.0054 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 236 | Open wounds of extremities | 2.40% | 1.80% | 0.60% | 34% | 0.0918 | $19 | $336 | $21 | $506 | −$2 | 0.8 | 0.1 | 2.3 | 0.1 | 1.2 | 0.1 | 0.3 | ||
| 113 | Late effects of cerebrovascular disease | 0.80% | 0.20% | 0.60% | 268% | 0.0001 | $31 | $1,253 | $1 | $63 | $30 | 0.3 | 0 | 0.9 | 0 | 0.5 | 0 | 0.4 | ||
| 224 | Other perinatal conditions | 0.80% | 0.20% | 0.60% | 364% | <0.0001 | $2 | $46 | $0 | $29 | $2 | 0.2 | 0 | 0.3 | 0 | 0.1 | 0 | 0 | ||
| 123 | Influenza | 2.10% | 1.50% | 0.60% | 37% | 0.097 | $36 | $1,297 | $6 | $156 | $30 | 0.3 | 0.1 | 1.1 | 0 | 0.6 | 0 | 0.1 | ||
| 112 | Transient cerebral ischemia | 0.90% | 0.40% | 0.50% | 116% | 0.0081 | $10 | $229 | $4 | $139 | $6 | 0.3 | 0.1 | 1.2 | 0 | 0.9 | 0 | 0.1 | ||
| 661 | Substance-related disorders | 3.80% | 3.30% | 0.50% | 15% | 0.3138 | $23 | $426 | $34 | $1,027 | −$11 | 0.5 | 0.2 | 2.7 | 0.3 | 6.9 | −0.1 | 0.2 | ||
| 167 | Nonmalignant breast conditions | 4.70% | 4.30% | 0.50% | 11% | 0.3958 | $27 | $317 | $30 | $451 | −$4 | 0.7 | 0.2 | 1.8 | 0.2 | 1.2 | 0 | 0.5 | ||
| 107 | Cardiac arrest and ventricular fibrillation | 0.60% | 0.10% | 0.40% | 317% | 0.0003 | $124 | $4,755 | $1 | $52 | $123 | 0.3 | 0.1 | 1.8 | 0 | 0.6 | 0.1 | 0.2 | ||
| 660 | Alcohol-related disorders | 1.60% | 1.20% | 0.40% | 36% | 0.149 | $16 | $316 | $28 | $1,146 | −$12 | 0.4 | 0.1 | 1.2 | 0.1 | 2.1 | 0 | 0.9 | ||
| 36 | Cancer of thyroid | 0.60% | 0.20% | 0.40% | 162% | 0.0071 | $9 | $239 | $3 | $154 | $6 | 0.3 | 0.1 | 1.9 | 0 | 0.5 | 0.1 | 0.2 | ||
| 147 | Anal and rectal conditions | 1.60% | 1.20% | 0.40% | 34% | 0.1762 | $6 | $150 | $7 | $196 | −$1 | 0.8 | 0 | 0.6 | 0 | 0.7 | 0 | 0.7 | ||
| 98 | Essential hypertension | 22.10% | 21.70% | 0.40% | 2% | 0.723 | $33 | $156 | $43 | $287 | −$9 | 0.1 | 0.6 | 2.3 | 0.7 | 2.4 | −0.1 | 0.4 | ||
| 214 | Digestive congenital anomalies | 0.60% | 0.20% | 0.40% | 194% | 0.0045 | $1 | $22 | $1 | $50 | $0 | 1 | 0 | 0.1 | 0 | 0.2 | 0 | 0.6 | ||
| 79 | Parkinson`s disease | 0.50% | 0.20% | 0.40% | 246% | 0.0023 | $6 | $120 | $2 | $106 | $4 | 0.2 | 0 | 0.5 | 0 | 0.4 | 0 | 0.2 | ||
| 234 | Crushing injury or internal injury | 0.60% | 0.20% | 0.40% | 178% | 0.0068 | $3 | $57 | $12 | $1,103 | −$10 | 0.4 | 0 | 0.4 | 0 | 0.4 | 0 | 0.5 | ||
| 9 | Sexually transmitted infections (not HIV or hepatitis) | 0.80% | 0.40% | 0.40% | 97% | 0.0344 | $3 | $40 | $1 | $25 | $2 | 0 | 0 | 0.2 | 0 | 0.2 | 0 | 0.3 | ||
| ### | Adverse effects of medical drugs | 0.90% | 0.50% | 0.40% | 70% | 0.0703 | $2 | $77 | $0 | $15 | $2 | 0.4 | 0 | 0.5 | 0 | 0.1 | 0 | 0.2 | ||
| ### | External cause codes: Struck by; against | 0.70% | 0.40% | 0.30% | 94% | 0.0475 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 24 | Cancer of breast | 1.40% | 1.00% | 0.30% | 34% | 0.2117 | $61 | $1,589 | $72 | $2,194 | −$11 | 0.8 | 0.2 | 3.9 | 0.3 | 7.4 | 0 | 0.7 | ||
| 115 | Aortic; peripheral; and visceral artery aneurysms | 0.80% | 0.50% | 0.30% | 67% | 0.0934 | $186 | $7,461 | $2 | $71 | $184 | 0.3 | 0 | 0.9 | 0 | 0.3 | 0 | 0.2 | ||
| 119 | Varicose veins of lower extremity | 1.00% | 0.70% | 0.30% | 44% | 0.1806 | $5 | $109 | $7 | $164 | −$1 | 0.7 | 0 | 0.4 | 0 | 0.7 | 0 | 0.9 | ||
| 6 | Hepatitis | 1.00% | 0.70% | 0.30% | 42% | 0.2009 | $2 | $43 | $11 | $538 | −$8 | 0.2 | 0 | 0.5 | 0.1 | 1.7 | 0 | 0.2 | ||
| 35 | Cancer of brain and nervous system | 0.40% | 0.10% | 0.30% | 400% | 0.0019 | $74 | $2,005 | $8 | $577 | $67 | 0.2 | 0.1 | 1.6 | 0 | 1.9 | 0 | 0.4 | ||
| ### | External cause codes: Natural/environment | 1.10% | 0.80% | 0.30% | 34% | 0.2558 | $0 | $0 | $0 | $2 | $0 | 0.3 | 0 | 0 | 0 | 0 | 0 | 0.3 | ||
| 656 | Impulse control disorders NEC | 0.40% | 0.10% | 0.30% | 329% | 0.0043 | $0 | $7 | $0 | $25 | $0 | 0.5 | 0 | 0.1 | 0 | 0.5 | 0 | 0.3 | ||
| 174 | Female infertility | 0.50% | 0.30% | 0.30% | 105% | 0.0643 | $18 | $394 | $3 | $130 | $15 | 0.1 | 0.1 | 1.2 | 0 | 1.2 | 0 | 0.5 | ||
| 213 | Cardiac and circulatory congenital anomalies | 0.80% | 0.50% | 0.30% | 55% | 0.1643 | $2 | $59 | $33 | $1,597 | −$31 | 0.1 | 0 | 0.3 | 0 | 1.4 | 0 | 0.1 | ||
| 176 | Contraceptive and procreative management | 4.30% | 4.00% | 0.20% | 6% | 0.6363 | $16 | $159 | $21 | $318 | −$5 | 0.4 | 0.1 | 1.1 | 0.1 | 1.2 | 0 | 0.8 | ||
| 201 | Infective arthritis and osteomyelitis (except that caused by tuberculosis or sexually transmitted disease) | 0.40% | 0.20% | 0.20% | 150% | 0.0402 | $31 | $1,232 | $5 | $233 | $27 | 0.4 | 0 | 1.1 | 0 | 0.8 | 0 | 0.5 | ||
| 207 | Pathological fracture | 0.50% | 0.20% | 0.20% | 111% | 0.0703 | $2 | $40 | $3 | $174 | −$1 | 0.5 | 0 | 0.2 | 0 | 0.2 | 0 | 0.7 | ||
| 124 | Acute and chronic tonsillitis | 1.20% | 0.90% | 0.20% | 27% | 0.3429 | $5 | $117 | $8 | $208 | −$4 | 0.3 | 0 | 0.5 | 0 | 0.7 | 0 | 0.5 | ||
| ### | External cause codes: Overexertion | 0.50% | 0.20% | 0.20% | 100% | 0.0905 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 169 | Endometriosis | 0.50% | 0.30% | 0.20% | 73% | 0.1502 | $8 | $224 | $4 | $290 | $5 | 0.5 | 0 | 0.8 | 0 | 0.4 | 0 | 0.3 | ||
| 170 | Prolapse of female genital organs | 0.50% | 0.30% | 0.20% | 73% | 0.1502 | $2 | $46 | $0 | $11 | $2 | 0.2 | 0 | 0.3 | 0 | 0.1 | 0 | 0.2 | ||
| 242 | Poisoning by other medications and drugs | 0.80% | 0.50% | 0.20% | 41% | 0.2672 | $56 | $2,267 | $8 | $369 | $47 | 0.4 | 0 | 0.8 | 0 | 0.7 | 0 | 0.7 | ||
| 165 | Inflammatory conditions of male genital organs | 0.90% | 0.70% | 0.20% | 29% | 0.3602 | $6 | $201 | $3 | $171 | $3 | 0.6 | 0 | 0.8 | 0 | 0.4 | 0 | 0.3 | ||
| 41 | Cancer; other and unspecified primary | 0.60% | 0.40% | 0.20% | 45% | 0.2763 | $2 | $39 | $2 | $82 | $0 | 0.8 | 0 | 0.2 | 0 | 0.2 | 0 | 0.3 | ||
| 1 | Tuberculosis | 0.20% | 0.00% | 0.20% | 567% | 0.004 | $1 | $39 | $0 | $6 | $1 | 0.2 | 0 | 0.3 | 0 | 0.1 | 0 | 0.3 | ||
| 37 | Hodgkin`s disease | 0.20% | 0.00% | 0.20% | 567% | 0.004 | $5 | $144 | $0 | $11 | $4 | 0.2 | 0.1 | 1.6 | 0 | 0.2 | 0 | 0.2 | ||
| 240 | Burns | 0.40% | 0.20% | 0.20% | 94% | 0.1279 | $1 | $44 | $2 | $94 | $0 | 0.8 | 0 | 0.2 | 0 | 0.7 | 0 | 0.5 | ||
| 184 | Early or threatened labor | 0.50% | 0.30% | 0.20% | 74% | 0.1714 | $14 | $354 | $5 | $214 | $9 | 0.3 | 0 | 0.5 | 0 | 0.5 | 0 | 0.9 | ||
| 22 | Melanomas of skin | 0.70% | 0.50% | 0.20% | 36% | 0.3376 | $20 | $564 | $6 | $184 | $14 | 0.3 | 0.1 | 1.4 | 0 | 0.7 | 0 | 0.4 | ||
| 215 | Genitourinary congenital anomalies | 0.50% | 0.30% | 0.20% | 67% | 0.2052 | $0 | $6 | $1 | $27 | $0 | 0.3 | 0 | 0.1 | 0 | 0.2 | 0 | 0.3 | ||
| 191 | Polyhydramnios and other problems of amniotic cavity | 0.40% | 0.20% | 0.20% | 100% | 0.1428 | $12 | $309 | $6 | $204 | $7 | 0.4 | 0 | 0.4 | 0 | 0.4 | 0 | 0.4 | ||
| 15 | Cancer of rectum and anus | 0.20% | 0.10% | 0.20% | 300% | 0.0253 | $3 | $102 | $0 | $4 | $3 | 0.3 | 0 | 0.2 | 0 | 0 | 0 | 0.2 | ||
| 26 | Cancer of cervix | 1.40% | 1.20% | 0.20% | 15% | 0.5428 | $6 | $170 | $3 | $87 | $2 | 0.6 | 0 | 0.5 | 0 | 0.4 | 0 | 0.8 | ||
| 99 | Hypertension with complications and secondary hypertension | 2.20% | 2.10% | 0.20% | 9% | 0.6423 | $10 | $293 | $21 | $683 | −$11 | 0.3 | 0 | 0.6 | 0.1 | 1.2 | 0 | 0.3 | ||
| ### | External cause codes: Other specified; NEC | 0.20% | 0.10% | 0.20% | 233% | 0.0476 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 152 | Pancreatic disorders (not diabetes) | 0.60% | 0.40% | 0.20% | 39% | 0.3548 | $1 | $35 | $17 | $430 | −$16 | 0 | 0 | 0.1 | 0.1 | 1.6 | −0.1 | 0 | ||
| 144 | Regional enteritis and ulcerative colitis | 0.80% | 0.60% | 0.20% | 27% | 0.4324 | $48 | $1,228 | $13 | $606 | $35 | 0.3 | 0.1 | 2.2 | 0.1 | 1.3 | 0.1 | 0.2 | ||
| 143 | Abdominal hernia | 2.20% | 2.10% | 0.10% | 7% | 0.7121 | $37 | $1,193 | $43 | $938 | −$7 | 0.8 | 0.1 | 1.2 | 0.1 | 1.5 | 0 | 0.5 | ||
| 659 | Schizophrenia and other psychotic disorders | 0.80% | 0.70% | 0.10% | 19% | 0.5634 | $23 | $883 | $10 | $324 | $13 | 0.6 | 0.3 | 9.9 | 0.1 | 1.4 | 0.2 | 0.4 | ||
| ### | Adverse effects of medical care | 0.20% | 0.00% | 0.10% | 275% | 0.0629 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 225 | Joint disorders and dislocations; trauma-related | 2.90% | 2.80% | 0.10% | 4% | 0.7878 | $39 | $562 | $36 | $465 | $4 | 0.8 | 0.3 | 3.8 | 0.2 | 3 | 0.1 | 0.5 | ||
| 28 | Cancer of other female genital organs | 0.20% | 0.10% | 0.10% | 200% | 0.1137 | $10 | $362 | $1 | $42 | $9 | 0.3 | 0 | 0.7 | 0 | 0.2 | 0 | 0.3 | ||
| 221 | Respiratory distress syndrome | 0.10% | 0.00% | 0.10% | Large | 0.0016 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 187 | Malposition; malpresentation | 0.30% | 0.20% | 0.10% | 67% | 0.3168 | $3 | $95 | $3 | $178 | $0 | 1 | 0 | 0.1 | 0 | 0.2 | 0 | 0.7 | ||
| 247 | Lymphadenitis | 1.40% | 1.20% | 0.10% | 10% | 0.6908 | $5 | $126 | $5 | $129 | $0 | 0.9 | 0 | 0.5 | 0 | 0.5 | 0 | 0.8 | ||
| 19 | Cancer of bronchus; lung | 0.40% | 0.20% | 0.10% | 43% | 0.438 | $12 | $458 | $49 | $1,895 | −$36 | 0.1 | 0 | 1.2 | 0.1 | 4.1 | −0.1 | 0.2 | ||
| 139 | Gastroduodenal ulcer (except hemorrhage) | 0.50% | 0.40% | 0.10% | 25% | 0.5476 | $0 | $12 | $9 | $496 | −$8 | 0.1 | 0 | 0.1 | 0 | 0.9 | 0 | 0.1 | ||
| 45 | Maintenance chemotherapy; radiotherapy | 0.60% | 0.50% | 0.10% | 22% | 0.5721 | $89 | $1,912 | $208 | $6,034 | −$119 | 0.1 | 0.2 | 5.2 | 0.2 | 5.4 | 0 | 0.9 | ||
| 110 | Occlusion or stenosis of precerebral arteries | 1.10% | 1.00% | 0.10% | 10% | 0.693 | $3 | $41 | $7 | $309 | −$4 | 0.3 | 0 | 0.2 | 0 | 0.5 | 0 | 0.1 | ||
| 54 | Gout and other crystal arthropathies | 1.50% | 1.40% | 0.10% | 8% | 0.7329 | $1 | $26 | $1 | $27 | $0 | 0.9 | 0 | 0.2 | 0 | 0.4 | 0 | 0.3 | ||
| 18 | Cancer of other GI organs; peritoneum | 0.20% | 0.10% | 0.10% | 114% | 0.2577 | $53 | $1,835 | $3 | $266 | $50 | 0.3 | 0 | 1.4 | 0 | 1.6 | 0 | 0.5 | ||
| 38 | Non-Hodgkin`s lymphoma | 0.40% | 0.30% | 0.10% | 36% | 0.4984 | $10 | $357 | $44 | $2,322 | −$34 | 0.2 | 0 | 0.9 | 0.1 | 5.8 | −0.1 | 0.2 | ||
| 182 | Hemorrhage during pregnancy; abruptio placenta; placenta previa | 0.50% | 0.40% | 0.10% | 25% | 0.5708 | $16 | $535 | $5 | $307 | $11 | 0.4 | 0.1 | 1.7 | 0 | 0.5 | 0 | 0.3 | ||
| 25 | Cancer of uterus | 0.20% | 0.10% | 0.10% | 88% | 0.345 | $14 | $564 | $5 | $265 | $9 | 0.5 | 0.1 | 2.1 | 0 | 1.1 | 0 | 0.6 | ||
| 189 | Previous C-section | 0.20% | 0.20% | 0.10% | 54% | 0.4473 | $6 | $258 | $14 | $465 | −$7 | 0.4 | 0 | 0.5 | 0 | 0.5 | 0 | 1 | ||
| 195 | Other complications of birth; puerperium affecting management of mother | 1.00% | 0.90% | 0.10% | 8% | 0.7832 | $20 | $400 | $20 | $531 | $1 | 1 | 0.1 | 1.6 | 0.1 | 1.5 | 0 | 0.5 | ||
| 27 | Cancer of ovary | 0.20% | 0.10% | 0.10% | 50% | 0.5349 | $34 | $1,005 | $26 | $1,444 | $8 | 0.8 | 0.1 | 2.7 | 0.1 | 4.4 | 0 | 1 | ||
| 177 | Spontaneous abortion | 0.20% | 0.10% | 0.10% | 50% | 0.5349 | $0 | $8 | $0 | $10 | $0 | 0.9 | 0 | 0.1 | 0 | 0.2 | 0 | 0.6 | ||
| ### | External cause codes: Suffocation | 0.10% | 0.00% | 0.10% | Large | 0.0253 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 116 | Aortic and peripheral arterial embolism or thrombosis | 0.10% | 0.10% | 0.10% | 100% | 0.3979 | $0 | $1 | $0 | $8 | $0 | 0.2 | 0 | 0 | 0 | 0.2 | 0 | 0.2 | ||
| 228 | Skull and face fractures | 0.20% | 0.10% | 0.00% | 36% | 0.6324 | $6 | $220 | $2 | $98 | $4 | 0.4 | 0 | 0.2 | 0 | 0.2 | 0 | 0.9 | ||
| 180 | Ectopic pregnancy | 0.10% | 0.00% | 0.00% | 400% | 0.2059 | $1 | $26 | $0 | $0 | $1 | 0.3 | 0 | 0 | 0 | 0 | 0 | 0.4 | ||
| 223 | Birth trauma | 0.10% | 0.00% | 0.00% | 400% | 0.2059 | $0 | $2 | $0 | $0 | $0 | 0.3 | 0 | 0 | 0 | 0 | 0 | 0.3 | ||
| 241 | Poisoning by psychotropic agents | 0.10% | 0.00% | 0.00% | 400% | 0.2059 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 132 | Lung disease due to external agents | 0.10% | 0.10% | 0.00% | 67% | 0.5269 | $0 | $2 | $1 | $84 | −$1 | 0.3 | 0 | 0.2 | 0 | 0.2 | 0 | 0.7 | ||
| ### | External cause codes: Cut/pierce | 0.30% | 0.20% | 0.00% | 19% | 0.7254 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 78 | Other CNS infection and poliomyelitis | 0.10% | 0.00% | 0.00% | 150% | 0.4385 | $0 | $0 | $0 | $2 | $0 | 0.3 | 0 | 0 | 0 | 0 | 0 | 0.3 | ||
| 248 | Gangrene | 0.10% | 0.10% | 0.00% | 43% | 0.6546 | $0 | $0 | $0 | $16 | $0 | 0.1 | 0 | 0 | 0 | 0.2 | 0 | 0.1 | ||
| ### | External cause codes: Other specified and classifiable | 0.20% | 0.10% | 0.00% | 25% | 0.7288 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 5 | HIV infection | 0.30% | 0.30% | 0.00% | 14% | 0.796 | $8 | $276 | $6 | $430 | $2 | 0.8 | 0.1 | 2.6 | 0 | 1.1 | 0.1 | 0.4 | ||
| 42 | Secondary malignancies | 0.50% | 0.40% | 0.00% | 8% | 0.8411 | $8 | $241 | $27 | $766 | −$18 | 0.1 | 0 | 0.5 | 0.1 | 1.2 | 0 | 0.1 | ||
| 203 | Osteoarthritis | 7.10% | 7.10% | 0.00% | 0% | 0.9587 | $108 | $2,261 | $168 | $2,697 | −$60 | 0.3 | 0.3 | 3.3 | 0.4 | 4.4 | −0.1 | 0.2 | ||
| 40 | Multiple myeloma | 0.10% | 0.00% | 0.00% | 67% | 0.6547 | $0 | $1 | $16 | $1,500 | −$16 | 0.3 | 0 | 0 | 0.1 | 4.3 | 0 | 0.3 | ||
| 17 | Cancer of pancreas | 0.10% | 0.00% | 0.00% | 25% | 0.8414 | $0 | $8 | $4 | $311 | −$4 | 0.2 | 0 | 0.1 | 0 | 1.1 | 0 | 0.3 | ||
| 148 | Peritonitis and intestinal abscess | 0.10% | 0.10% | 0.00% | 11% | 0.8927 | $0 | $1 | $1 | $36 | −$1 | 0.1 | 0 | 0 | 0 | 0.3 | 0 | 0.1 | ||
| 39 | Leukemias | 0.20% | 0.20% | 0.00% | 5% | 0.9256 | $331 | $11,820 | $37 | $2,273 | $294 | 0.3 | 0.9 | 25 | 0.1 | 6.4 | 0.8 | 0.2 | ||
| 12 | Cancer of esophagus | 0.10% | 0.10% | 0.00% | 0% | 1 | $0 | $1 | $4 | $301 | −$4 | 0.2 | 0 | 0.1 | 0 | 1 | 0 | 0.2 | ||
| 29 | Cancer of prostate | 0.70% | 0.70% | 0.00% | 0% | 1 | $57 | $1,661 | $69 | $2,320 | −$13 | 0.8 | 0.1 | 2.1 | 0.2 | 5.1 | −0.1 | 0.3 | ||
| 31 | Cancer of other male genital organs | 0.00% | 0.00% | 0.00% | 0% | 1 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 43 | Malignant neoplasm without specification of site | 0.20% | 0.20% | 0.00% | 0% | 1 | $3 | $84 | $1 | $44 | $2 | 0.3 | 0 | 0.3 | 0 | 0.2 | 0 | 0.3 | ||
| 179 | Postabortion complications | 0.00% | 0.00% | 0.00% | 0% | 1 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 192 | Umbilical cord complication | 0.20% | 0.20% | 0.00% | 0% | 1 | $0 | $0 | $1 | $72 | −$1 | 0.1 | 0 | 0 | 0 | 0.2 | 0 | 0.1 | ||
| 194 | Forceps delivery | 0.00% | 0.00% | 0.00% | 0% | 1 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 219 | Short gestation; low birth weight; and fetal growth retardation | 0.10% | 0.10% | 0.00% | 0% | 1 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 220 | Intrauterine hypoxia and birth asphyxia | 0.00% | 0.00% | 0.00% | 0% | 1 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
| 226 | Fracture of neck of femur (hip) | 0.20% | 0.20% | 0.00% | 0% | 1 | $17 | $693 | $26 | $1,200 | −$9 | 0.7 | 0 | 0.8 | 0.1 | 3.1 | 0 | 0.4 | ||
| ### | External cause codes: Drowning/submersion | 0.00% | 0.00% | 0.00% | 0% | 1 | $0 | $0 | $0 | $0 | $0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
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