Whole Tumour CT Perfusion in Non-Small Cell Lung Cancer: Evaluation of Perfusion Parameters Prior to Initiation of Therapy
- 1. Department of Radio-Diagnosis, Indira Gandhi Medical College, India
- 2. Management Studies, Bharathidasan Institute of Management, India
- 3. Department of Pulmonary Medicine, Indira Gandhi Medical College, India
abstract
Objectives: To analyse and correlate the perfusion parameters measured by CT perfusion with different histological sub-types, stage and location of tumour and tumour volume in cases of Non-small cell lung cancer prior to initiation of therapy.
Materials and Methods: 85 patients with proven Non-small cell lung cancer underwent CT perfusion in a 64 slice multi-detector CT scanner. Whole tumour perfusion parameters - blood flow (BF, ml/100g/min), blood volume (BV, ml/100g), mean transit time (MTT, seconds) and permeability surface area product (PS, ml/100g/min) were measured. Each perfusion parameter was analysed and correlated with each other and with different histological sub-types, stage, location and volume of the tumour.
Results: There was statistically significant difference in BF, MTT and PS values in >50 cm3 and ≤50 cm3tumour volume groups (p= 0.001, 0.021 and 0.019 respectively). There was no statistically significant difference in perfusion parameters among different histological sub-types, stage and location of tumour, however, BV, BF and MTT values were higher in adenocarcinoma than in squamous cell carcinoma and higher in stage IV than in stage IIIB, BV and BF values were higher in central tumours than in peripheral tumours and MTT values were higher in peripheral tumours than in central tumours. There was strong positive correlation between BF and BV (r=0.7873, p<0.0001), BF and PS (r=0.6719, p<0.0001) and BV and PS (r=0.5793, p<0.0001). There was weak correlation between BF and tumour volume (r=0.3589, p=0.0298), MTT and BV (r=0.4275, p=0.0019) and location of tumour and histological sub-type of tumour (r=0.3838, p=0.0118).
Conclusion: CT perfusion done prior to initiation of therapy revealed significant correlation within perfusion parameters and also with tumour volume. Perfusion parameters may be related to tumour volume. No significant difference in perfusion parameters were found among different histological sub-types, stage and location of tumour.