JSM Physical Medicine and Rehabilitation

Functional Mobility in Mechanically Ventilated Critically ill Patients: An Observational Study

Research Article | Open Access

  • 1. Escuela de Kinesiología, Facultad de Ciencias de la Rehabilitación, Universidad Andres Bello, Santiago, Chile
  • 2. Centro de Paciente Crítico Adulto, Clínica INDISA, Chile
  • 3. Departamento de Salud Pública y Epidemiología, Universidad de los Andes, Santiago, Chile
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Corresponding Authors
Felipe A. González Seguel, Centro de Paciente Crítico Adulto Clínica INDISA, Avenida Santa María 1810, Providencia, Santiago, Chile, Tel: 56-9-89540683

Objective: The aim of this study was to describe the functional mobility (FM) both on awakening and at intensive care unit (ICU) discharge. Secondarily, it aimed to explore the correlation between FM with deep sedation, mechanical ventilation, ICU delirium and absolute bed rest.

Materials and Methods: A descriptive study was performed in a medical and surgical ICU for one year among mechanically ventilated patients with previous functional independence. The FM was assessed with the Functional Status Score for the Intensive Care Unit (FSS-ICU) on awakening and at ICU discharge. Limb strength was assessed with the Medical Research Council Sum Score (MRC SS).

Results: From the 80 patients analyzed, the FSS-ICU resulted with 17 points on awakening and 26 points at ICU discharge. Exploration between FSS-ICU on awakening and deep sedation showed a negative correlation (rho= 0.39? p=0.000). Exploration between the FSS-ICU at ICU discharge and days on mechanical ventilation showed a negative correlation (rho=0.36? p=0.001), as well as the presence of ICU delirium (rho=0.25? p=0.027) and days with absolute bed rest (rho= 0.31, p=0.005). When exploring the presence of intensive care unit acquired weakness (ICU-AW) on awakening and the number of days under deep sedation, there was a statistically significant association (odds ratio = 0.1 [95% CI 0.035 to 0.275]).

Conclusions: Approximately one in four patients had ICU-AW and one in five patients were discharged from the ICU without being able to walk or with complete assistance.


González Seguel FA, Lee Goic JE, Cárcamo Ibaceta ME, Blaitt Convalia AA, Castillo Merino FA, et al. (2017) Functional Mobility in Mechanically Ventilated Critically ill Patients: An Observational Study. JSM Physical Med Rehabil 1(2): 1007.


•    Functional mobility
•    Intensive care
•    Physiotherapy
•    Early ambulation
•    Mechanical ventilation


FM: Functional Mobility; s5Q: Standardized 5 Questions Scale; CAM-ICU: Confusion Assessment Method for the ICU; MRC SS: Medical Research Council Sum Score; FSS-ICU: Functional Status Score for the Intensive Care Unit; MIP: Maximum Inspiratory Pressure/Force; NMES: Neuromuscular Electrical Stimulation; ICU: Intensive Care Unit; ARDS: Acute Respiratory Distress Syndrome; COPD: Chronic Obstructive Pulmonary Disease; APACHE II: Acute Physiology and Chronic Health Evaluation II; ICU-AW: Intensive Care Unit-Acquired Weakness


Patients in intensive care units (ICU) remain hospitalized for a long time, leading to physical deterioration and the onset of health complications [1,2]. This is due to prolonged mechanical ventilation, deep sedation, high severity of illness at admission, delirium, prolonged bed rest, among others. These factors contribute to impaired functional status, causing physical, psychological and cognitive sequelae [3]. One of the syndromes that are commonly associated with the deterioration of functional status is the intensive care unit acquired weakness (ICU-AW). The ICU-AW is defined as the symmetric weakness of extremities acquired by factors associated to ICU stay, affecting from 25% to 50% of critically ill patients[1].

Currently, the assessment of functional status has taken up relevance in clinical studies as it is considered an important indicator in the decision-making process in healthcare [4,5]. Functional status considers the quality and quantity of daily activities a person can do consciously. Among them is the mobility of the whole body, which includes transfers, maintenance of posture and walking? The performance of these activities is one of the main goals in physiotherapy intervention [6], which is named by some authors as “functional mobility” (FM) [6,7]. All of these activities associated with mobility are codified in Chapter 4 of Activities and Participation (d4) of the International Classification of Functioning, Disability and Health (ICF)[7].

The importance of maintaining and recovering the FM during ICU stay is to prevent the negative effects after ICU stay. These are related to the productivity of survivors after hospital discharge, delaying their return to work and to family duties, decreasing the availability of hospital beds and ultimately raising healthcare costs [8-10]. It is therefore relevant to obtain an assessment and approach on FM in critically ill patients in an early and opportune manner [11,12]. Functional mobility of patients is usually low on awakening and at ICU discharge[13], causing functional problems after the ICU stay [14].

Physiotherapy has progressively been incorporated in Chile as part of the interdisciplinary ICU team [15] and plays an important role in facilitating activity. However, in Chile the ICU FM levels and its association with different risk factors are unknown, like in many other countries. The aim of this study was to describe the FM both on awakening and at ICU discharge in two ICUs in Chile. Secondarily, it aimed to explore the correlation of FM with the days under deep sedation, days on mechanical ventilation, presence of ICU delirium and total days with absolute bed rest. In addition, the association between the presence of ICU-AW on awakening and the days under deep sedation was explored. The hypothesis of the present study is that the FM measured through FSS-ICU has more than 5 points of change from ICU awakening to ICU discharge [13,16].


Patients were admitted to medical and surgical ICU of Clínica INDISA from March 2nd, 2015 to March 2nd, 2016. This ICU had 2 units of 8 beds each, with university affiliation and acted as teaching centers. The inclusion criteria to participate in the study were: 1) 48 or more hours on invasive mechanical ventilation [IMV] or non-invasive ventilation; 2) 72 or more hours on ICU stay; and 3) prior functional independence defined by Karnofsky Performance Scale (KPS) [17] > 70%. The exclusion criteria are shown in the flow reference diagram on Figure 1. This study was approved by the Ethics Committee Servicio Metropolitano Oriente, Santiago, Chile (N°CECOriente-161214) on December 2014. All the included patients or their legal representative signed an informed consent before the study initiated.

To avoid potential sources of bias, six trained physiotherapists recorded the daily assessment results from the scales on a sheet of operational control, specifying the presence or absence of risk factors suggested by the literature and sociodemographic data. They also registered the medical indication for physiotherapy, which is given by the physician on a daily basis to all patients requiring mechanical ventilation. The physiotherapy session included passive mobilization, positioning and progressive FM facilitation. In the center selected for the study, physiotherapists are responsible for respiratory therapy, too. The duration of physiotherapy ranged from 60 to 120 minutes per 12 hours for each ICU patient according to the Physiotherapy Daily Assessment [Supplementary material 1]. Currently there is no formal clinical practice guide for mobilizing patients in the center, thus the intensity and progression depend on each physiotherapists. Sedation, glycemia and mechanical ventilation weaning protocols are routinely used. The sedation protocol includes light sedation and a daily wake-up trial.


The severity of illness of the first 24 hours was assessed using the Acute Physiology and Chronic Health Evaluation II (APACHE II) [18]. This scale has a score that ranges point from 0 – 71.

On awakening, defined as the first time that the patient was able to answer 5 simple orders (Standardized Five Questions - s5Q) [1], the Medical Research Council Sum Score (MRC SS) was assessed [1,19]. If the patient had an indication for initiating activity out of bed, FM was assessed with the FSS-ICU [12,16]. This scale takes into account 5 items that refers to activities related to mobility: rolling, supine to sit transfer, sitting on the edge of the bed, sit to stand transfer and walking. Each item has a score that ranges from 0 to 7 (see Supplementary material 4 for details). The total score range for the FSS-ICU goes from 0 to 35 points, with higher scores indicating better FM. “Dismobility” is a concept that was used in this study to refer to the difficulty in activities associated with FM. The version of the FSS-ICU used in this study is being validated in Spanish language. MRC SS and FSS-ICU were assessed on awakening and at ICU discharge according to the clinical stability criteria described in Supplementary material 3.

The presence of ICU-AW was defined with a MRC SS <48 points [1] and the presence of ICU delirium with the CAM-ICU [20] (Confusion Assessment Method for the ICU) testing positive at least once a day.

The patient was considered with “Deep Sedation” when the patient presented a Sedation-Agitation Scale (SAS) < 3 points for more than 12 hours a day, and “Absolute Bed Rest” when the patient remained at least one day in bed without even getting into the seated position at the edge of the bed. For analyzing purposes, the “days under deep sedation” was dichotomized in > 3 days and ≤ 3 days [3], the “days on invasive mechanical ventilation” were dichotomized at > 4 days and ≤ 4 days [3] and of “total days with absolute bed rest” was dichotomized into > 6 days and ≤ 6 days [21].

Statistical analysis

Quantitative variables were reported through medians and interquartile ranges (IQR), and the qualitative variables were reported using absolute and relative frequencies. The variables considered for analysis were: FM (assessed with FSS-ICU), limb strength (assessed with MRC Sum Score), days with absolute bed rest, days on mechanical ventilation, days with ICU delirium, days under deep sedation, among others.

Correlation of the FSS-ICU on awakening with the days under deep sedation was explored. The correlation between FSS-ICU at ICU discharge and days on mechanical ventilation with the presence of ICU delirium and total days with absolute bed rest was explored. In addition, the association between the presence of ICU-AW on awakening and the days under deep sedation was explored. The exploration of correlations was analyzed with rho Spearman and associations with odds ratio. Results are presented through graphs and tables. For the explorations, a confidence level of 95% was taken into account. Data was analyzed using software (StataCorp LLC, Texas USA; https://www.stata.com/).


From the 779 patients admitted at the center on the period covered by the study, 144 met the inclusion criteria. Considering the exclusion criteria and withdrawn, the analyzed sample was 80 patients, as shown in the flow diagram (Figure 1). Baseline characteristics of patients are described in Table 1. Patients had a median age of 54 years old (IQR 25 - 64.5) and 26 (32%) of them were female. The median APACHE II score was 20 (IQR 14 - 26.50) points. From the 80 patients analyzed, 28 (35%) had an admission diagnosis of acute respiratory distress syndrome (ARDS) and 25 (31.25%) had sepsis. The number of days on IMV was 7 (IQR 4 – 12) that match with the number of days to the first sitting edge of the bed in ICU.

The results for the assessment of FM and strength are described in Table 2. The 53.75% of patients on awakening presented ICU-AW while at ICU discharge it was only 26.25%. Regarding the walking item on awakening, 45% of the patients had < 2 points on FSS-ICU score and only 18.75% scored <2 points when measured at ICU discharge.

The results of the analyses can be seen in Figure (2). The exploration between the FSS-ICU on awakening and deep sedation showed a negative and statistically significant correlation (rho=- 0.39; p=0.000). Exploration between the FSS-ICU at ICU discharge and days on invasive mechanical ventilation showed a negative and statistically significant correlation (rho=-0.36; p=0.001), as well with the presence of ICU delirium (rho=-0.25; p=0.027) and total days with absolute bed rest (rho= -0.31, p=0.005). On exploring, the presence of ICU-AW on awakening with the number of days under deep sedation, there was a statistically significant association (odds ratio = 0.1 [95% CI 0.035 to 0.275]).

Table 1: Baseline characteristics of patients.

Characteristics n=80*
Age (years) 54 (25-64.5)
Female 26 (32%)
Body-mass index (kg/m) 28 (24.7-32.5)
Admission diagnosis:
Cardiac Surgery
COPD exacerbation
Other diagnosis
28 (35%)
25 (31.25%)
6 (7.5%)
5 (6.25%)
4 (5%)
12 (15%)
APACHE II score 20 (14-26.5)
ICU length of stay (days) 13 (9-19.5)
Mechanical ventilation (days) 7 (4-12)
Non invasive ventilation (days) 2 (0-5.5)
ICU delirium (days) 0 (0-3)
Days to first sit on the edge of the bed 7 (4-10)
a Absolute bed rest (days) 8 (5-12.5)
a Absolute bed rest, % ICU days 61.5%
b Deep sedation in ICU (days) 4 (2-7)
b Deep sedation, % ICU days 30.7%
Corticosteroids in ICU (days) 7 (0-12.5)
Vasopressor in ICU (days) 2 (0-3)
Number of patients with neuromuscular blocker Neuromuscular blocker (hours) 16 (20%)
60 (15-108)
Number of patients with renal replacement therapy Renal replacement therapy (days) 11 (13.75%)
7 (2-9)
*Values are presented as median (25 - 75% quartiles) or patient 
number (%).
a Day in which the patient did not even sit on the edge of the bed, but bed 
mobility was allowed.
b Defined with Sedation-Agitation Scale less than 3 points (1 or 2 points) 
for more than 12 hours in the day.
Abbreviations: ARDS: Acute Respiratory Distress Syndrome; COPD: 
Chronic Obstructive Pulmonary Disease; APACHE II: Acute Physiology 
and Chronic Health Evaluation II; ICU: Intensive Care Unit

Table 2: Limb Strength and Functional Mobility in ICU.

Strength and Functional Mobility (n=80)* ICU Awakening ICU discharge
MRC Sum Score 44 (35.5-55) 52 (47-58)
ICU-AWa 43 (53.75%) 21 (26.25%)
FSS-ICU 17 (10-23) 26 (19.5-32)
Rolling 3 (2-5.5) 6 (4-7)
Supine to Sit Transfer 3 (2-4) 4,5 (3-7)
Sitting at the edge of the bed 5 (3.5-6) 7 (6-7)
Sit to Stand Transfer 3 (2-4) 5 (3,5-7)
Walking 2 (0-4) 4 (3-5,5)
Complete dependence in Walkingb 36 (45%) 15 (18.8%)
*Values are presented as median (25 - 75% quartiles) or patient 
number (%).
The presence of ICU-AW was defined with a MRC SS <48 points.
b Patient is unable to attempt or complete the task of walking due to 
weakness or can walk less than 15 meters with the physical assistance 
of one or two peoples (severe dismobility).
Abbreviations: MRC SS: Medical Research Council Sum Score; FSS-ICU: 
Functional Status Score for the Intensive Care Unit; ICU-AW: Intensive 
Care Unit-Acquired Weakness.



Active mobilization and rehabilitation in ICU improved body function, functional activity and social participation [22]. The selection of an appropriate measuring instruments to identify changes in physical functioning is paramount [5]. This study aims to describe the changes in FM of critically ill patients through the FSS-ICU. There are coincidences with other studies that have used the FSS-ICU [23,24] that had shown changes in FM from awakening to ICU discharge. However, there are differences to published literature. For example in 2010, Zanni et al. [12], had an increase in the median score of the FSS-ICU of 4 points from awakening to ICU discharge (10/35 to 14/35, respectively), whereas in the present study the difference was 9 points (17/35 to 26/35, respectively).There are external factors that influence changes in the FM, such as the type of patients, the differences in the criteria for ICU discharge and the priorities of the center.

Some authors have shown that the minimal important difference in the FSS-ICU, both on awakening and on ICU discharge, goes from 2 to 5 points of the total score, with a minimum floor and ceiling effect (between 0% and 3%) [13,16]. It is also disclosed that the highest scores of the FSS-ICU in ICU are predictive of direct home discharge, without requiring special care or institutionalization after discharge [13,16,25]. The results from these studies suggest that the differences in FM that arose in the current explorations have clinical relevance.

Others factors that determine worse outcomes in physical functioning and which have been considered barriers to FM are: deep sedation, absolute bed rest, mechanical ventilation and ICU delirium [3,26]. Thus, the variables that were explored in this study regarding FM and ICU-AW were selected based on the evidence, and bear relation to the ABCDE bundle intervention strategy [27]. This multi-professional strategy emphasizes optimizing team work in the ICU, standardization of care processes, priority in reducing sedation, facilitation of early mobilization and extubation [28]. The variables measured in this study represent the problems associated with each of the interventions that make up the ABCDE bundle: days under deep sedation (Awakening), days on mechanical ventilation (Breathing Coordination), presence of ICU delirium (Delirium monitoring/management) and days with absolute bed rest (Early exercise/mobility). The aim was to find out whether these variables determined by the literature are of clinical use in the study center’s population, and they are discussed below.

Days under deep sedation

Recent evidence has led to limiting the use of deep sedation as part of routine management of patients on mechanical ventilation to anticipate patient’s awakening time [29]. In this research the proportion of the days under deep sedation in relation to total days in ICU was 30.7%, while in a prospective study from Fan et al, it was 29% [30]. However, this study shows that patients with more than 3 days under deep sedation demonstrate a significant decrease in FM on awakening when compared to those who were deeply sedated ≤ 3 days (Figure 2A). This difference seems important to keep in mind for further analysis, since several studies have associated deep sedation with complications related to mobility, longer hospital stays, delirium, increased mortality, prolonged mechanical ventilation, as well as long-term cognitive and depressive symptoms [3,31].

Days on mechanical ventilation

The international current strategy seeks to reduce the days on mechanical ventilation in order to minimize associated complications [27]. The explorations of this study describe those patients who spend more than 4 days on mechanical ventilation in the ICU showed decreased FM at ICU discharge, in contrast to those who were on mechanical ventilation less than 4 days (Figure 2B).

ICU delirium

In this study, the incidence of delirium was 44%, with duration from one to three days. The detected delirium was not described based on its hypoactive, hyperactive and mixed phenotypes. The prevalence of ICU delirium described in other studies is 16 to 80%, with higher incidence in patients presenting septic shock and invasive mechanical ventilation [27].

It was determined in this study that there is a statistically significant correlation between the presence of ICU delirium and decreased FM at ICU discharge (Figure 2C).

Delirium has a negative impact on the functional status of patients hospitalized in medical and surgical ICU [27,32], which is associated with physical disability after hospital discharge.

Days with absolute bed rest

Bed rest has a proven correlation with the loss of muscle mass and of other functions (cardiovascular, energy metabolism, respiratory functions, others] that negatively impact the performance of FM [3].That is why it is recommended to have indicators that avoid the presence of immobilized patients without explicit medical order [33].

This study considered the amount of absolute days without out of bed activity for patients in the ICU, unlike other studies showing the number of days until the first activities are performed out of bed [sitting edge of bed] [12] or some other functional milestone [standing or walking] [34]. Although there should be similarity, the variable used in this study more fully represents the total number of days without getting up in the ICU, making it a more suitable indicator for comparison between different centers.

In the current study sample, patients with more than 6 days with absolute bed rest during hospitalization showed a clinically significant decrease in FM at ICU discharge (Figure 2D), compared with patients with more than 6 days with absolute bed rest. The variable “Absolute bed rest” requires further analysis due to the potential benefit that could mean to early and more frequent out of bed activity in critically ill patients.

Functional mobility/dismobility

Based on the scale proposed by the ICF [7], dismobility was determined as the presence of severe difficulty [0 and 1 point in the FSS-ICU-walking score]. Taking this into account, 19% of patients of this sample were discharged from ICU with severe walking dismobility. This means that patients cannot attempt or complete the task of walking due to weakness or can walk less than 15 meters with the physical assistance of one or two peoples. This is important to emphasize because the quality of walking is described as a predictor of mortality and morbidity [35,36]. Early mobilization has been shown to cause a greater probability of walking without assistance at hospital discharge [22].

Besides, FM involves the synergistic interaction between many functions/structures, such as pain, muscle functions, respiratory functions, balance, motivation, exercise tolerance, etc[11]. Therefore, there is still a knowledge gap separating these functions with the concept of dismobility.

Relevance and clinical utility

To systematically assess the ICU functional activities as part of the care process, and how it improves the quality of care, this study used the FSS-ICU instrument.

The FSS-ICU was feasible and easy to apply, both on awakening and at discharge, since the 5 assessed activities are performed routinely in the context of the ICU, as described in other studies [13].

The importance of this study is that it generates an objective knowledge basis on FM, being the first study of this kind in Chile. The KPS, s5Q, CAM-ICU, MRC SS and FSS-ICU are used as an assessment battery. These instruments generate clinically relevant adherence and are still used as part of the daily practice by physiotherapist of the ICU. There is a tendency to assess more than just mortality as a clinical outcome in the ICU, but also aspects associated with FM that could have an impact on physical functioning, well being and quality of life of the post-discharge patient [37].


There are several potential limitations in this present work. First the sample was taken from only two critically ill patient units for the same center, which may limit the accuracy and generalization of these results. Second, due to the observational design of this report, the causal effect for weakness and dismobility cannot be assessed. Finally, there are currently no validated scales available in Chile to assess FM in the ICU. Therefore, in this work the version of the FSS-ICU available at www.improvelto.com was used.


In conclusion, approximately one in four patients had ICU-AW and one in five patients had complete dependence to walking at ICU discharge. In addition, an improvement in FM for patients was documented from awakening to ICU discharge. The present study underlines the negative effect of deep sedation with absolute bed rest. Future studies should provide more information about the quality of walking and FM within the ICU and its consequences.


The authors wish to acknowledge the Equipo de Kinesiología Intensiva y Terapia Respiratoria Centro de Paciente Crítico Adulto Clínica INDISA for their assistance in carrying out the study, for evaluation and monitoring of patients. Special acknowledgements to physiotherapists: Alejandro Arriagada, Francisco Castro, Domingo Torres, Oscar Arellano, Fabián Guzmán and Macarena Wainer for helping in the translation. In addition, due to their collaboration in the development of the study, the authors wish to acknowledge the nursing and physician staff of Clínica INDISA, who worked with the patients that were a part of our study.


This work was performed on Centro de Paciente Crítico Adulto Clínica INDISA, Santiago, Chile and the authors have not disclosed any potential conflicts of interest.


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Received : 09 Nov 2017
Accepted : 13 Dec 2017
Published : 15 Dec 2017
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JSM Arthritis
ISSN : 2475-9155
Launched : 2016
JSM Head and Neck Cancer-Cases and Reviews
ISSN : 2573-1610
Launched : 2016
JSM General Surgery Cases and Images
ISSN : 2573-1564
Launched : 2016
JSM Anatomy and Physiology
ISSN : 2573-1262
Launched : 2016
JSM Dental Surgery
ISSN : 2573-1548
Launched : 2016
Annals of Emergency Surgery
ISSN : 2573-1017
Launched : 2016
Annals of Mens Health and Wellness
ISSN : 2641-7707
Launched : 2017
Journal of Preventive Medicine and Health Care
ISSN : 2576-0084
Launched : 2018
Journal of Chronic Diseases and Management
ISSN : 2573-1300
Launched : 2016
Annals of Vaccines and Immunization
ISSN : 2378-9379
Launched : 2014
JSM Heart Surgery Cases and Images
ISSN : 2578-3157
Launched : 2016
Annals of Reproductive Medicine and Treatment
ISSN : 2573-1092
Launched : 2016
JSM Brain Science
ISSN : 2573-1289
Launched : 2016
JSM Biomarkers
ISSN : 2578-3815
Launched : 2014
JSM Biology
ISSN : 2475-9392
Launched : 2016
Archives of Stem Cell and Research
ISSN : 2578-3580
Launched : 2014
Annals of Clinical and Medical Microbiology
ISSN : 2578-3629
Launched : 2014
JSM Pediatric Surgery
ISSN : 2578-3149
Launched : 2017
Journal of Memory Disorder and Rehabilitation
ISSN : 2578-319X
Launched : 2016
JSM Tropical Medicine and Research
ISSN : 2578-3165
Launched : 2016
JSM Head and Face Medicine
ISSN : 2578-3793
Launched : 2016
JSM Cardiothoracic Surgery
ISSN : 2573-1297
Launched : 2016
JSM Bone and Joint Diseases
ISSN : 2578-3351
Launched : 2017
JSM Bioavailability and Bioequivalence
ISSN : 2641-7812
Launched : 2017
JSM Atherosclerosis
ISSN : 2573-1270
Launched : 2016
Journal of Genitourinary Disorders
ISSN : 2641-7790
Launched : 2017
Journal of Fractures and Sprains
ISSN : 2578-3831
Launched : 2016
Journal of Autism and Epilepsy
ISSN : 2641-7774
Launched : 2016
Annals of Marine Biology and Research
ISSN : 2573-105X
Launched : 2014
JSM Health Education & Primary Health Care
ISSN : 2578-3777
Launched : 2016
JSM Communication Disorders
ISSN : 2578-3807
Launched : 2016
Annals of Musculoskeletal Disorders
ISSN : 2578-3599
Launched : 2016
Annals of Virology and Research
ISSN : 2573-1122
Launched : 2014
JSM Renal Medicine
ISSN : 2573-1637
Launched : 2016
Journal of Muscle Health
ISSN : 2578-3823
Launched : 2016
JSM Genetics and Genomics
ISSN : 2334-1823
Launched : 2013
JSM Anxiety and Depression
ISSN : 2475-9139
Launched : 2016
Clinical Journal of Heart Diseases
ISSN : 2641-7766
Launched : 2016
Annals of Medicinal Chemistry and Research
ISSN : 2378-9336
Launched : 2014
JSM Pain and Management
ISSN : 2578-3378
Launched : 2016
JSM Women's Health
ISSN : 2578-3696
Launched : 2016
Clinical Research in HIV or AIDS
ISSN : 2374-0094
Launched : 2013
Journal of Endocrinology, Diabetes and Obesity
ISSN : 2333-6692
Launched : 2013
Journal of Substance Abuse and Alcoholism
ISSN : 2373-9363
Launched : 2013
JSM Neurosurgery and Spine
ISSN : 2373-9479
Launched : 2013
Journal of Liver and Clinical Research
ISSN : 2379-0830
Launched : 2014
Journal of Drug Design and Research
ISSN : 2379-089X
Launched : 2014
JSM Clinical Oncology and Research
ISSN : 2373-938X
Launched : 2013
JSM Bioinformatics, Genomics and Proteomics
ISSN : 2576-1102
Launched : 2014
JSM Chemistry
ISSN : 2334-1831
Launched : 2013
Journal of Trauma and Care
ISSN : 2573-1246
Launched : 2014
JSM Surgical Oncology and Research
ISSN : 2578-3688
Launched : 2016
Annals of Food Processing and Preservation
ISSN : 2573-1033
Launched : 2016
Journal of Radiology and Radiation Therapy
ISSN : 2333-7095
Launched : 2013
Annals of Clinical Pathology
ISSN : 2373-9282
Launched : 2013
Annals of Cardiovascular Diseases
ISSN : 2641-7731
Launched : 2016
Journal of Behavior
ISSN : 2576-0076
Launched : 2016
Annals of Clinical and Experimental Metabolism
ISSN : 2572-2492
Launched : 2016
Clinical Research in Infectious Diseases
ISSN : 2379-0636
Launched : 2013
JSM Microbiology
ISSN : 2333-6455
Launched : 2013
Journal of Urology and Research
ISSN : 2379-951X
Launched : 2014
Journal of Family Medicine and Community Health
ISSN : 2379-0547
Launched : 2013
Annals of Pregnancy and Care
ISSN : 2578-336X
Launched : 2017
JSM Cell and Developmental Biology
ISSN : 2379-061X
Launched : 2013
Annals of Aquaculture and Research
ISSN : 2379-0881
Launched : 2014
Clinical Research in Pulmonology
ISSN : 2333-6625
Launched : 2013
Journal of Immunology and Clinical Research
ISSN : 2333-6714
Launched : 2013
Annals of Forensic Research and Analysis
ISSN : 2378-9476
Launched : 2014
JSM Biochemistry and Molecular Biology
ISSN : 2333-7109
Launched : 2013
Annals of Breast Cancer Research
ISSN : 2641-7685
Launched : 2016
Annals of Gerontology and Geriatric Research
ISSN : 2378-9409
Launched : 2014
Journal of Sleep Medicine and Disorders
ISSN : 2379-0822
Launched : 2014
JSM Burns and Trauma
ISSN : 2475-9406
Launched : 2016
Chemical Engineering and Process Techniques
ISSN : 2333-6633
Launched : 2013
Annals of Clinical Cytology and Pathology
ISSN : 2475-9430
Launched : 2014
JSM Allergy and Asthma
ISSN : 2573-1254
Launched : 2016
Journal of Neurological Disorders and Stroke
ISSN : 2334-2307
Launched : 2013
Annals of Sports Medicine and Research
ISSN : 2379-0571
Launched : 2014
JSM Sexual Medicine
ISSN : 2578-3718
Launched : 2016
Annals of Vascular Medicine and Research
ISSN : 2378-9344
Launched : 2014
JSM Biotechnology and Biomedical Engineering
ISSN : 2333-7117
Launched : 2013
Journal of Hematology and Transfusion
ISSN : 2333-6684
Launched : 2013
JSM Environmental Science and Ecology
ISSN : 2333-7141
Launched : 2013
Journal of Cardiology and Clinical Research
ISSN : 2333-6676
Launched : 2013
JSM Nanotechnology and Nanomedicine
ISSN : 2334-1815
Launched : 2013
Journal of Ear, Nose and Throat Disorders
ISSN : 2475-9473
Launched : 2016
JSM Ophthalmology
ISSN : 2333-6447
Launched : 2013
Journal of Pharmacology and Clinical Toxicology
ISSN : 2333-7079
Launched : 2013
Annals of Psychiatry and Mental Health
ISSN : 2374-0124
Launched : 2013
Medical Journal of Obstetrics and Gynecology
ISSN : 2333-6439
Launched : 2013
Annals of Pediatrics and Child Health
ISSN : 2373-9312
Launched : 2013
JSM Clinical Pharmaceutics
ISSN : 2379-9498
Launched : 2014
JSM Foot and Ankle
ISSN : 2475-9112
Launched : 2016
JSM Alzheimer's Disease and Related Dementia
ISSN : 2378-9565
Launched : 2014
Journal of Addiction Medicine and Therapy
ISSN : 2333-665X
Launched : 2013
Journal of Veterinary Medicine and Research
ISSN : 2378-931X
Launched : 2013
Annals of Public Health and Research
ISSN : 2378-9328
Launched : 2014
Annals of Orthopedics and Rheumatology
ISSN : 2373-9290
Launched : 2013
Journal of Clinical Nephrology and Research
ISSN : 2379-0652
Launched : 2014
Annals of Community Medicine and Practice
ISSN : 2475-9465
Launched : 2014
Annals of Biometrics and Biostatistics
ISSN : 2374-0116
Launched : 2013
JSM Clinical Case Reports
ISSN : 2373-9819
Launched : 2013
Journal of Cancer Biology and Research
ISSN : 2373-9436
Launched : 2013
Journal of Surgery and Transplantation Science
ISSN : 2379-0911
Launched : 2013
Journal of Dermatology and Clinical Research
ISSN : 2373-9371
Launched : 2013
JSM Gastroenterology and Hepatology
ISSN : 2373-9487
Launched : 2013
Annals of Nursing and Practice
ISSN : 2379-9501
Launched : 2014
JSM Dentistry
ISSN : 2333-7133
Launched : 2013
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