Exophytic Lymphoma of the Uterus Identified by 18-FDG PET Scan
- 1. Department of Radiology, University of Kentucky, USA
- 2. Department of Pathology, University of Kentucky, USA
Sinha P, Nair RT, Ganesh H, Purdom MS, Krohmer SJ, et al. (2013) Exophytic Lymphoma of the Uterus Identified by 18-FDG PET Scan. J Radiol Radiat Ther 1(2): 1014.
A 56 year old woman with stage IV follicular lymphoma presenting with bilateral axillary and inguinal lymphadenopathy seven years back was treated by chemotherapy at an outside institution and had been in remission since past five years. She then presented with a right groin mass, which on excisional biopsy was reportedly positive for lymphoma. PET/CT scan performed in a Siemens Biograph 6 after 70 minutes of incubation following the intravenous administration of 13.2 mCi 18-F fluorodeoxyglucose (FDG) with a blood glucose of 100 mg/dl showed an intensely hypermetabolic 4.9 x 4.3 x 4.2 cm exophytic mass with a maximum SUV of 31.4 arising from the uterine fundus. No other hypermetabolic abnormalities were identified in the PET/CT scan (Figure 1).
The role of 18-F FDG PET/CT scans in the diagnosis and staging of lymphomas is well established in the literature . Uterine lymphomas are rare tumors [2-8]. The cases described in the literature have typically demonstrated, diffuse or focal involvement of the uterus, intravascular involvement or presentation as an endometrial polyp. Exophytic appearance of uterine lymphomas appears to be unusual. Hypermetabolism in the uterus can be identified in various conditions such as menstruation, post partum status or lymphomas . This case illustrates the importance of including exophytic lymphomas of the uterus in the differential of pelvic hypermetabolic masses.
5. Lannoo L, Smets S, Steenkiste E, Delforge M, Moerman P, Stroobants S, et al. Intravascular large B-cell lymphoma of the uterus presenting as fever of unknown origin (FUO) and revealed by FDG-PET. Acta Clin Belg. 2007; 62: 187-190.
6. Rittenbach J, Cao JD, Weiss LM, Rowsell EH, Chick W, Wang J. Primary diffuse large B-cell lymphoma of the uterus presenting solely as an endometrial polyp. International journal of gynecological pathology: official. Journal of the International Society of Gynecological Pathologists. 2005; 24: 347-351.