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Annals of Clinical Pathology

Cellular and Gene Therapies in Multiple Myeloma: Standard of Care and Future Directions

Review Article | Open Access | Volume 13 | Issue 1
Article DOI :

  • 1. Division of Hematology, The Ohio State University Comprehensive Cancer Center, USA
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Corresponding Authors
Elvira Umyarova, Division of Hematology, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA, Tel: 9176089137
Abstract

Background: Multiple myeloma (MM) remains incurable despite >10 new drugs since 2015. Engineered cellular therapies may eradicate resistant plasma-cell clones.

Objective: To summarize current evidence on cellular and gene therapies in MM and identify major knowledge gaps and future directions.

Methods: PubMed, CENTRAL, ClinicalTrials.gov, and ASH/ASCO/ESMO abstracts from 2020–2025 were searched for preclinical and phase I–III studies of cellular or gene-engineered therapies for MM, including CAR-T, CAR-NK, γδ T-cell, and TCR-engineered products. Twelve studies met eligibility criteria, including 11 clinical studies and 1 preclinical study.

Results: FDA-approved CAR-T products ide-cel and cilta-cel achieve >70 % ORR. Memory-enriched, Early-phase studies of memory-enriched, fully human, and T stem cell memory–enriched constructs have reported ORRs ranging from 48% to 100%, although cross-trial comparisons are limited and longer follow-up is needed to assess persistence and safety. Allogeneic BCMA CAR-T, iPSC- BCMA CAR-NK and anti-CD38 γδ-CAR-T exhibit low acute toxicity yet limited in-vivo durability. Non-BCMA or dual-antigen CARs deliver high ORR, while TCR-T is active in HLA-A*02:01-positive disease.

Conclusions: BCMA-directed CAR-T therapy is an established treatment option in RRMM. Broader integration of cellular therapies will require randomized comparative trials, biomarker-driven patient selection, long-term safety registries for gene-edited products, faster manufacturing, and improved cost-effectiveness

Keywords

• Multiple myeloma

• CART product

• Gene editing

• Gene engineered T cells

citation

: Umyarova E (2026) Cellular and Gene Therapies in Multiple Myeloma: Standard of Care and Future Directions. Ann Clin Pathol 13(1): 1182.

INTRODUCTION

Multiple myeloma (MM) accounts for about 1% of all cancers and it is the second most common hematological malignancy after lymphoma. MM develops when post-germinal-center B-cells acquire certain somatic chromosomal mutations, such as t(11;14), t (4;14) or del17p, and 1q gain, leading to clonal plasma-cell proliferation within the bone-marrow. Malignant plasma cells oversecrete monoclonal immunoglobulin and free light chains that cause end-organ damage – hypercalcemia, renal failure, anemia and bony lesions. Commonly presenting symptoms include bone/back pain, fatigue, recurrent infections and pathological fractures collectively called CRAB criteria. Diagnosis of MM requires Diagnosis of MM requires clonal bone marrow plasma cells ≥10% or biopsy-proven plasmacytoma, plus one or more myeloma-defining events. These include CRAB features attributable to the plasma-cell disorder or specific biomarkers of malignancy, such as clonal marrow plasma cells ≥60%, involved/uninvolved serum free light-chain ratio ≥100, or more than one focal lesion on MRI., more than 60 % 

of clonal plasma cells, serum FLC ratio more than 100, or more than 1 focal bony lesions on MRI. The later criteria were added by International Myeloma Working Group in 2014 [1].

MM is the disease of the elderly with the median age at diagnosis of 69 years old with more than 95% of the cases occurring in patients above 50 years old. Men and African Americans have higher incidence than women and Whites [2]. According to the American Cancer Society, an estimated 36,110 new cases of multiple myeloma are diagnosed in the United States each year. Patients with high-risk cytogenetics (del17p, t(4;14), 1q gain) or plasma-cell leukemia have more aggressive disease biologically and clinically with the short duration of response, PFS and OS [3].

Virtually all symptomatic MM is preceded by an asymptomatic precursor state, such as MGUS and smoldering multiple myeloma. of uncertain clinical significance (MGUS) and smoldering MM and first-degree relatives of the patients with known MM diagnosis carry a 2- to 4-fold increased risk compared to general population [4]. At current state of science effective chemoprevention is not defined, although there are populations studies, one of most famous is called “I StopMM”, that are testing for MGUS screening and early interventions [5].

Despite more than ten FDA approvals since 2015, MM remains incurable. Deep and durable remissions are rare, cumulative toxicities and the financial burden increase with each subsequent line, and researchers are in need to develop new targets to control MM and search for treatment options to overcome the drug resistance

BACKGROUND

MM arises from clonally expanded plasma cells, that synthesize large amount if immunoglobulin, depend on proteasome-mediated protein disposal and remodel the bone marrow microenvironment to suppress immunity. Therefore, current standard of care front-line therapies rely on blocking proteosomal degradation, direct cytotoxicity and antibody-dependent cellular cytotoxicity in order to successfully lower the clonal cell population. Front line regimens include triplet or quadruplet chemotherapy combinations - proteasome inhibitors (PI), eg. bortezomib, immunomodulatory drugs (IMiDS), eg. Lenalidomide, with or without anti-CD38 mAB, eg. Daratumumab, plus corticosteroids with subsequent early autologous stem-cell transplant autologous hematopoietic cell transplantation and maintenance lenalidomide. autologous hematopoietic cell transplantation is the reinfusion of the autologous stem cells that is intended to prolong PFS, and is an effective option especially for HRMM patients, although it would be a poor option for older and frail patients.

Relapsed/refractory (RRMM) disease develops over time in most of the patients with various times for disease progression mainly depending on the genetic risk for the disease. RRMM is managed with consecutive use of next-generation PIs, IMiDs, anti-CD38, BCMA, anti-SLAMF7 antibodies, exportin-1 inhibitor selinexor, bispecific T-cell engagers, and alkylators [15], each line leading to lower depth and duration of response with increased cumulative toxicity. The main mechanisms of action for those medications include inhibition of proteasome units, cereblon modulation and recruitment of BCMA antigen, important for survival of plasma cells.

Although these regimens have extended median overall survival (mOS) beyond six years, every patient eventually becomes “class–refractory,” at which point overall survival (OS) drops below one year. Outcomes worsen substantially once patients develop triple-class-refractory disease, defined as refractoriness to a proteasome inhibitor, an IMiD, and an anti-CD38 monoclonal antibody. Reported median overall survival is approximately 8–9 months, and may fall to 5–6 months in penta-refractory disease. [6]. Together, these statistics highlight the pressing need for more durable, less toxic therapeutics in RRMM. An ideal treatment strategy would eradicate resistant plasma-cell clones while restoring durable immune surveillance. highly resistant plasma-cell clones and re-establish long-term immune control.

Cell and gene therapies, especially CAR-T cells, are showing promise in fulfilling the need for effective treatment in RRMM. There are 2 BCMA-directed autologous CAR-T products — idecabtagene vicleucel (Abecma) and ciltacabtagene autoleucel (Carvykti), that had been approved by FDA in 2021 and 2022, respectively, with one-time infusions achieving more than 70–95 % overall response rate (ORR) in heavily pre-treated RRMM with durable duration of response (DoR) up to 35 months [7,8].

Utilizing the same or similar concept, several next-generation cell therapy treatment modalities were constructed to attempt to prove safety and efficacy. These treatment modalities are currently in the various stages of the clinical trials and not yet FDA approved for commercial use (Table 1).

Table 1: Several next-generation cell therapy treatment modalities were constructed to attempt to prove safety and efficacy

 

Allogeneic off-the-shelf CAR-T, eg.

Allo-715

designed to shorten vein-to-vein time and improve access for patients who have no time to wait for 4-6 weeks for autologous CART processing [9]

Dual-target CARTs, for example BCMA/CD19 CART cell products using fasTCAR platforms,

allow to recruit additional cell surface targets for high-risk MM (HRMM) and shorten the processing times [10]

A non-BCMA CART constructs for example GPRC5D – CART cells

Are utilizing additional antigens on plasma cell surface rather than already saturated BCMA space [11]

Engineered natural-killer (CAR-NK) and γδ-T cells

They have less systemic toxicity while providing antimyeloma effects [12]

 

CRISPR and other gene-editing strategies

yet to gain more attention in MM but available data in gene editing is promising, allowing T cells to facilitate expansion and persistence and, eventually, potency [13].

 

TCR-engineered T cells

This treatment modality intends to attack MM without utilizing the surface antigens and might be a promising strategy for highly RRMM that is lacking surface antigens [14].

METHODS/LITERATURE SEARCH

The literature search was performed on May 15, 2025, across three electronic databases PubMed, Cochrane CENTRAL, and ClinicalTrials.gov as well as three conference annals - American Society of Hematology, American Society of Clinical Oncology and European Society of Medical Oncology. Each source was investigated from January 1, 2015, to May 15, 2025. Original articles or conference papers with completed pre-clinical translational or phase I–III clinical data were included into the search that included search terms “engineered cellular or gene-edited product directed against multiple myeloma”. Terms autologous or allogeneic CAR-T, CAR-NK, TCR-T, CRISPR-modified cells were included. Studies with at least one efficacy endpoint- ORR, PFS, MRD were included in search. Ongoing trials without posted results were excluded, as well as bispecific antibodies or cytokine therapies without a gene-modified cell product. Only primary study literature was included in this report with no addition of reviews, editorials or non-myeloma malignancies. Data extraction included study aim, study design, product characteristics, population, and key outcomes.

784 records were evaluated and after removal of 148 duplicates, 636 titles were identified and 538 were excluded, leaving 98 full-text articles. 86 did not meet search criteria (filtered through lack of results, insufficient data, disease type, type of therapy), leaving researcher with 12 studies -11 clinical and 1 preclinical studies for the detailed analysis (Figure 1) (Table 2 and Table 3).

https://www.jscimedcentral.com/public/assets/images/uploads/image-1777349779-1.jpg

Figure 1 Figure presents a flowchart.

Our search was confined to English written articles only, some studies lack a fully published manuscripts and only included conference abstracts, studies with negative results might be underrepresented. Our cut-off date is May 15, 2025, so studies listed after this date were not included in this manuscript.

Table 2: Integrated review chart table

Citation

Study aim

Study design

Study population

Key findings

 

Munshi NC et al., 2021 KarMMa [16]

Evaluate efficacy and safety of autologous BCMA-CAR-T in triple-class–refractory MM

Phase 2, open-label, single-arm, multicenter clinical trial

128 adult patients with median 6 lines of prior therapy, refractory to PI; IMiDs and anti-

CD38-therapy

The key findings: ORR 73 %; ≥CR 33

%; median PFS 8.8 mo; Gr ≥3 CRS 5 %, ICANS 3 %

Berdeja J G et al., 2021 CARTITUDE-1 [17]

Determine safety and activity of dual-epitope BCMA- CAR-T

Phase 1/2, single-arm, multicenter clinical trial

97 patients with RRMM and 6 median prior lines of therapy

Key findings: ORR 97 %; sCR 67 %; Gr

≥3 CRS 4 %, ICANS 9 %

Alsina et al., 2020 CRB-402 [8]

Test memory-enriched BCMA-CAR-T for clinical outcomes like DoR

Phase 1 dose escalation/ expansion

68 patients with RRMM with median 6 prior lines of therapy; 57% triple refractory

Key findings: ORR 48 %; ≥CR 18%; mDOR 11.9 mo

Mailankody S et al., 2020 EVOLVE [19]

Assess fully human scFv BCMA-CAR-T for rsafety and efficacy

Phase 1, open label

51 patients with RRMM > 3 lines of therapy

Key findings: ORR 91 %; ≥CR 39 %; mPFS 9.3 mo; Gr ≥3 CRS 2 % NE ≥ 3: 4%

 

Wang D et al., 2021FUMANBA-1 [20]

Determine activity of fully human BCMA-CAR-T (CT103A) and

determine its safety and efficacy

 

Phase 1, single arm

18 patients with RRMM including patients previously exposed to murine BCMA-directed CAR constructs.

 

Key findings: ORR 100 %; sCR 72.2 %; 12-mo PFS 58.3 %;

Mailankody S et al., 2023

UNIVERSAL [9]

First-in-human off-the-shelf. allogeneic BCMA-CAR-T allo 715 evaluated for safety and tolerability

 

Phase 1, dose-escalation

 

43 patients with RRMM

Key findings: ORR 55.8 % mDoR 8.3 mo; Gr ≥3 CRS 2.3 %, no Gr ≥3 ICANS

Mailankody et al., 2022 MCARH109 [11] [23]

Target BCMA-independent antigen to prevent escape - GPRC5D CAR-T

 

Phase 1, first-in-human

17 patients with RRMM, heavily pre-treated, including relapsed post BCMA CART

 

Key findings: ORR 71 %;

Qiang W et al., 2024 GC012F [10]

Test dual-antigen CAR-T targeting BCMA/CD19

for deeper MRD negativity

Phase 1 single arm, open label, single center

 

22 patients with NDMM

Key findings: ORR 100 %; robust CART cell expansion with peak copy numbers at 10 days (9-14)

Gregory et al., Tscm CART [21]

Evaluate high purity engineered BCMA-CAR-T with T stem cell memory phenotype

Phase 1 single arm, open label

4 patients with RRMM more than 3 lines of therapy

Key findings: Favorable safety profile with no increase in CRS biomarkers.

 

Dhakal et all FR576 [12]

First of off-the-shelf iPSC-derived BCMA CAR-NK assessment of safety and tolerability

 

Phase 1, dose-escalation

 

9 patients with RRMM

Key findings: no dose limiting toxicities, no CRS, ICANS or GVHD

Rapoport AP et al., 2015 NY-ESO-1 TCR-T

post-ASCT [14]

Explore engineered TCR-T targeting intracellular antigen to investigate safety and activity

 

Phase I/II

20 antigen-positive MM pts post-ASCT

Key findings near CR/sCR 70 %; mPFS 19 mo; mOS 32.1 mo; no CRS/ICANS

Hattori Y., 2025 Anti-CD38 γδ-CAR-T [13]

Develop γδ-T CAR-T for off-the-shelf usevin tandem with allogeneic transplantation

 

Preclinical

in-vivo immunodeficient mice models; ex-vivo - patient samples

Potential antitumor effects in vivo, suppressing tumor growth.

Table 3: Study Evaluation

Citations

Strengths

Limitations

Future work

 

 

Munshi NC et al., 2021 KarMMa [7] Methodological journal (IF > 100)

The strengths of KarMMa study include multicenter, international design, prospective study, correlative work on biomarkers and dose exploration; no control arm leading to selection and confounding bias, open label

Single arm study, small lowest dose cohort, short follow up on overall survival, limited racial and ethnic diversity, no quality- of-life measures and no reports on manufacturing. Powered

to ORR, but not OS, underpowered

subgroup and dose level cohorts

 

 

Studies on increased persistence mitigation of toxicity long term safety

 

Berdeja J G et al., 2021 CARTITUDE-1 [17] (Journal with IF~ 28)

Multicenter clinical trials, Investigates the treatment for highly refractory population, constructs included dual-epitope BCMA, they have deep and durable efficacy endpoints Single arm, sponsor open leading to potential reporting bias

Single arm, open design, relatively small sample size, underrepresented and short median follow up, no quality of life assessment and limited details on manufacturing, not powered to PFS.

 

Evaluate for the earlier line, control of late neurotoxicity studies on combination and maintenance therapy post CART

 

Alsina et al., 2020 CRB-402 [8] (IF

>20)

First in human, multicenter, dose escalation trial, tests hypothesis to increase persistence, good signal on safety and efficacy in heavily treated population. No comparator and short follow up

Single arm study with relatively small sample short follow ups, complex manufacturing. US centers, might be hard to replicate

 

Phase II studies, investigation in earlier line and in earlier line and in combination, attempt to simplify the manufacturing.

 

Mailankody S et al., 2020 EVOLVE

[19] (IF 45)

This study tests fully human BCMA construct in heavily pretreated cohort with significant clinical efficacy and relatively stable safety. Since center investigator led study

 

Small sample size, short follow up time to assess the efficacy, concern for late infections. Exploratory study with CI

 

Randomized larger sample trials, combinations and maintenance trials.

 

 

Wang D et al., 2021FUMANBA-1

[20] (IF 7)

This study is testing fully human BCMA construct with lower immunogenicity. and higher persistence. Very good efficacy parameters and CART persistence. Single site

Single center study, small cohort, conducted only in China where some medications are not available. High grade CRS and prolonged cytopenias. Descriptive statistics in a single site, applicability can be questioned

 

 

How to mitigate high grade CRS, studies directed for extramedullary disease.

 

 

Mailankody S et al., 2023 UNIVERSAL [9] (IF > 100)

First study using allogeneic BCMA CART. Can potentially address the issues with autologous collections and manufacturing time, since it is off the shelf. No GVHD and severe CRS/ICANS. Complex eligibility

Complex manufacturing processes makes it expensive; unknown long term risks of gene editing: especially secondary malignancies, limited CART persistence,

less diverse patient population. Not powered for efficacy

 

Studies on secondary malignances, studies on durability of response, need direct comparison trials for autologous and allogeneic CART

 

Mailankody et al., 2022 MCARH109

[11] (short format for high IF

journal)

Testing the different CART beyond BCMA target, shows significant efficacy in high risk relapsed refractory population, might have potential combinations with BCMA CART. No comparator

Very small population, potential dose dependent toxicity and skin and mucosa associated side effects. Exploratory and not powered study

 

Need larger sample trials, limit dose related toxicities and head-to-head comparison with BITes

 

Qiang W et al., 2024 GC012F [10] (IF ~20)

First construct including dual CART product targeting 2 receptors: BCMA and CD19, quick manufacturing, favorable early signals on safety with no exceptional toxicity. Single center study.

 

Small study sample in single center, short follow up period, no details on manufacturing. Power not specified

 

Needs a bigger study, with larger sample, longer follow up study and studies on CART persistence.

 

Gregory et all Tscm CART [21] (brief research in high IF journal)

First in human evaluation of BCMA- CAR-T with T stem cell memory phenotype, favorable efficacy and safety profile, special effect on extramedullary disease. Very small design concern for observation bias

 

Very small sample, purely a signal seeking study that is not powered

 

Larger clinical trial for better definition of side effects and safety signals

 

 

Dhakal et all FR576 [12] (int IF journal)

This study tests clonally engineered NK cells – available off the shelf product, early safety profile is very favorable, this might increase accessibility being “off the shelf” product. Sponsor open labeled.

Expensive and time- consuming manufacturing, very small sample study, small combination sample – unknown efficacy in combination with daratumumab, no data on persistence.

Descriptive statistics

 

 

Larger studies on combinations, studies evaluating the persistence of the product

 

Rapoport AP et al., 2015 NY-ESO-1 TCR-T post-ASCT [14]

First TCR-T product that targets intracellular cancer antigen. Favorable efficacy data, and persistence data, no contemporary control

Might only fit a specific cohort of patients HLA - A*02:01 which is a minority of myeloma patients, single arm, small sample. Not powered beyond PFS, HLA population restricts generalizability

Need to consider additional targets to improve generalizability, consider combinations with currently approved

backbone treatments

 

 

Hattori Y., 2025 Anti-CD38 γδ-CAR-T [13]

The study uses allogeneic T cells, allowing to manufacture “off the shelf” product and increase accessibility good preclinical efficacy signaling; Unable to detect off target cytopenia risk

 

Minimal human myeloma lines, no data across multiple donors. Uncertain human translation.

Needs studies on DLT, long term persistence, distribution; considerations for clinical trials with combinations of currently approved myeloma backbone regimens and targets/ combination of targets.

DISCUSSION/CONCLUSION

Relapsed-refractory multiple myeloma (RRMM) still defies cure, and each subsequent line of standard therapy yields shallow and shorter-lived remissions. Engineered gene- and cell-based treatments have emerged as the modalities capable of eradicating highly drug-resistant plasma-cell clones and achieving molecular-level remissions and potentially durable responses. Studies presented in this systematic review attempt to provide an overview of the current landscape of the cellular therapy in multiple myeloma.

Autologous BCMA-CAR-T studies (e.g. ide-cel, cilta-cel, bb21217, CT103A, P-BCMA-101) share several features in common [16- 20]. They include rapid cytoreduction with more than 70 % overall response even in penta-refractory disease, manageable acute toxicities when current CRS/ ICANS treatments are applied, and a clear dose–response relationship for depth and persistence. Divergence appears in the tail of the curve and likely related to the CART cell persistence – for example cilta-cel and fully-human CT103A show more than 60 % 18-month PFS, whereas ide-cel and orva-cel plateau nearer 12 months. Factors driving these gaps are yet to be learned as patient biology and correlative studies analysis vary across different trials.

“Off-the-shelf” and non-BCMA CART products share some additional heterogeneity [9-12]. Universal ALLO-715 and FT576 NK data confirm that gene-edited allogeneic products can be infused safely with single-digit severe-CRS side effect rates, yet persistence rarely exceeds 2–3 months and mDOR remains about eight months.

Next arm of non-BCMA or dual CART products - GPRC5D  CAR-T  (MCARH109)  and  dual  BCMA/CD19

fasTCAR (GC012F) - demonstrate that recruiting different targets or enhancing BCMA leads to additional efficacy on RRMM, but skin and neuro-toxicities unique to GPRC5D, that happen in up to 30% pf the patients, and the uncertain incremental benefit along with the double side effect profile of dual targeting warrant additional larger studies [10, 11]. Dual CART products seek to avoid resistance with early studies reporting deeper MRD negativity but also additive cytopenia and CRS.

TCR-engineered NY-ESO-1 cells illustrate that an intracellular antigen target can achieve MRD-negative, multi-year remissions without CRS, yet generalizability is limited to HLA-A*02:01 patients, which includes minority of Western MM population [14].

Gene-edited T-cell (ALLO-715) and iPSC-derived CAR-NK (FT576) products eliminate the vein-to-vein delay and enable repeat dosing. Severe CRS or GvHD remain low, yet CAR/NK persistence rarely exceeds 2–3 months and median duration of response is approximately 8 months due to potential allo-immune rejection and lack of memory [9-12].

Additional targets under early clinical evaluation include CD38, CD138, CD229 investigate additional targets in post BCMA relapse. Clinical activity is still being investigated and the optional schedule is yet to be learned.

In addition, current research lacks knowledge on comparators and sequencing. There are no trials that would randomize against modern regimens as well as the optimal integration into sequence of therapy remains undefined in majority of the products undergoing the clinical trial. Another limitation includes long-term follow-ups. Long-term safety data assessments beyond three years are uncommon, data on T-cell exhaustion are still to be learned as well as effects on hypogammaglobulinemia, myelodysplasia and secondary malignancies mutagenesis risk, particularly for CRISPR- or iPSC-edited products. Published studies underreport access times, quality of lives and cost. Additional limitations include underrepresentation of the minority groups, despite higher incidence of MM in African American population, also lacking data on elderly patients and patients with renal failure.

Though most of the studies show positive results, those are mostly small sample phase-I/early phase-II studies that are still a subject for maturity, outside the scope of two FDA approved autologous BCMA products. Currently, there is insufficient evidence to replace autologous stem-cell transplants or FDA approved bispecific antibodies that carry no cellular vehicle and are fully manufactured off the shelf products.

Cellular therapy products certainly have great potential in addressing the unmet need in management of RRMM although further research is needed to provide evidence of efficacy and safety as well as good QoL and cost-effectiveness.

Next steps should include larger scale randomized clinical trials, comparison trials with the standard of care backbone treatments for RRMM, optimal sequencing of therapies, longer follow up periods for safety and efficacy as well as incorporation of the QoL questionnaires and geriatric fitness assessments. Additional preclinical studies on T cell exhaustion and persistence, determining mechanisms of antigen escape as well as optimization of the manufacturing and shortening the time from the bag to the vein [23]. Last but not least – creation of long- term registries to capture late toxicities and long-term survival outcomes.

The incurable nature of myeloma demands new treatment modalities and by proving that these cellular and gene constructs can deliver definitive, potentially curable and safe options would allow these treatments to be transitioned to frontline

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Umyarova E (2026) Cellular and Gene Therapies in Multiple Myeloma: Standard of Care and Future Directions. Ann Clin Pathol 13(1): 1182.

Received : 10 Feb 2026
Accepted : 02 Apr 2026
Published : 03 Apr 2026
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Journal of Autoimmunity and Research
ISSN : 2573-1173
Launched : 2014
JSM Arthritis
ISSN : 2475-9155
Launched : 2016
JSM Head and Neck Cancer-Cases and Reviews
ISSN : 2573-1610
Launched : 2016
JSM General Surgery Cases and Images
ISSN : 2573-1564
Launched : 2016
JSM Anatomy and Physiology
ISSN : 2573-1262
Launched : 2016
JSM Dental Surgery
ISSN : 2573-1548
Launched : 2016
Annals of Emergency Surgery
ISSN : 2573-1017
Launched : 2016
Annals of Mens Health and Wellness
ISSN : 2641-7707
Launched : 2017
Journal of Preventive Medicine and Health Care
ISSN : 2576-0084
Launched : 2018
Journal of Chronic Diseases and Management
ISSN : 2573-1300
Launched : 2016
Annals of Vaccines and Immunization
ISSN : 2378-9379
Launched : 2014
JSM Heart Surgery Cases and Images
ISSN : 2578-3157
Launched : 2016
Annals of Reproductive Medicine and Treatment
ISSN : 2573-1092
Launched : 2016
JSM Brain Science
ISSN : 2573-1289
Launched : 2016
JSM Biomarkers
ISSN : 2578-3815
Launched : 2014
JSM Biology
ISSN : 2475-9392
Launched : 2016
Archives of Stem Cell and Research
ISSN : 2578-3580
Launched : 2014
Annals of Clinical and Medical Microbiology
ISSN : 2578-3629
Launched : 2014
JSM Pediatric Surgery
ISSN : 2578-3149
Launched : 2017
Journal of Memory Disorder and Rehabilitation
ISSN : 2578-319X
Launched : 2016
JSM Tropical Medicine and Research
ISSN : 2578-3165
Launched : 2016
JSM Head and Face Medicine
ISSN : 2578-3793
Launched : 2016
JSM Cardiothoracic Surgery
ISSN : 2573-1297
Launched : 2016
JSM Bone and Joint Diseases
ISSN : 2578-3351
Launched : 2017
JSM Bioavailability and Bioequivalence
ISSN : 2641-7812
Launched : 2017
JSM Atherosclerosis
ISSN : 2573-1270
Launched : 2016
Journal of Genitourinary Disorders
ISSN : 2641-7790
Launched : 2017
Journal of Fractures and Sprains
ISSN : 2578-3831
Launched : 2016
Journal of Autism and Epilepsy
ISSN : 2641-7774
Launched : 2016
Annals of Marine Biology and Research
ISSN : 2573-105X
Launched : 2014
JSM Health Education & Primary Health Care
ISSN : 2578-3777
Launched : 2016
JSM Communication Disorders
ISSN : 2578-3807
Launched : 2016
Annals of Musculoskeletal Disorders
ISSN : 2578-3599
Launched : 2016
Annals of Virology and Research
ISSN : 2573-1122
Launched : 2014
JSM Renal Medicine
ISSN : 2573-1637
Launched : 2016
Journal of Muscle Health
ISSN : 2578-3823
Launched : 2016
JSM Genetics and Genomics
ISSN : 2334-1823
Launched : 2013
JSM Anxiety and Depression
ISSN : 2475-9139
Launched : 2016
Clinical Journal of Heart Diseases
ISSN : 2641-7766
Launched : 2016
Annals of Medicinal Chemistry and Research
ISSN : 2378-9336
Launched : 2014
JSM Pain and Management
ISSN : 2578-3378
Launched : 2016
JSM Women's Health
ISSN : 2578-3696
Launched : 2016
Clinical Research in HIV or AIDS
ISSN : 2374-0094
Launched : 2013
Journal of Endocrinology, Diabetes and Obesity
ISSN : 2333-6692
Launched : 2013
Journal of Substance Abuse and Alcoholism
ISSN : 2373-9363
Launched : 2013
JSM Neurosurgery and Spine
ISSN : 2373-9479
Launched : 2013
Journal of Liver and Clinical Research
ISSN : 2379-0830
Launched : 2014
Journal of Drug Design and Research
ISSN : 2379-089X
Launched : 2014
JSM Clinical Oncology and Research
ISSN : 2373-938X
Launched : 2013
JSM Bioinformatics, Genomics and Proteomics
ISSN : 2576-1102
Launched : 2014
JSM Chemistry
ISSN : 2334-1831
Launched : 2013
Journal of Trauma and Care
ISSN : 2573-1246
Launched : 2014
JSM Surgical Oncology and Research
ISSN : 2578-3688
Launched : 2016
Annals of Food Processing and Preservation
ISSN : 2573-1033
Launched : 2016
Journal of Radiology and Radiation Therapy
ISSN : 2333-7095
Launched : 2013
JSM Physical Medicine and Rehabilitation
ISSN : 2578-3572
Launched : 2016
Annals of Cardiovascular Diseases
ISSN : 2641-7731
Launched : 2016
Journal of Behavior
ISSN : 2576-0076
Launched : 2016
Annals of Clinical and Experimental Metabolism
ISSN : 2572-2492
Launched : 2016
Clinical Research in Infectious Diseases
ISSN : 2379-0636
Launched : 2013
JSM Microbiology
ISSN : 2333-6455
Launched : 2013
Journal of Urology and Research
ISSN : 2379-951X
Launched : 2014
Journal of Family Medicine and Community Health
ISSN : 2379-0547
Launched : 2013
Annals of Pregnancy and Care
ISSN : 2578-336X
Launched : 2017
JSM Cell and Developmental Biology
ISSN : 2379-061X
Launched : 2013
Annals of Aquaculture and Research
ISSN : 2379-0881
Launched : 2014
Clinical Research in Pulmonology
ISSN : 2333-6625
Launched : 2013
Journal of Immunology and Clinical Research
ISSN : 2333-6714
Launched : 2013
Annals of Forensic Research and Analysis
ISSN : 2378-9476
Launched : 2014
JSM Biochemistry and Molecular Biology
ISSN : 2333-7109
Launched : 2013
Annals of Breast Cancer Research
ISSN : 2641-7685
Launched : 2016
Annals of Gerontology and Geriatric Research
ISSN : 2378-9409
Launched : 2014
Journal of Sleep Medicine and Disorders
ISSN : 2379-0822
Launched : 2014
JSM Burns and Trauma
ISSN : 2475-9406
Launched : 2016
Chemical Engineering and Process Techniques
ISSN : 2333-6633
Launched : 2013
Annals of Clinical Cytology and Pathology
ISSN : 2475-9430
Launched : 2014
JSM Allergy and Asthma
ISSN : 2573-1254
Launched : 2016
Journal of Neurological Disorders and Stroke
ISSN : 2334-2307
Launched : 2013
Annals of Sports Medicine and Research
ISSN : 2379-0571
Launched : 2014
JSM Sexual Medicine
ISSN : 2578-3718
Launched : 2016
Annals of Vascular Medicine and Research
ISSN : 2378-9344
Launched : 2014
JSM Biotechnology and Biomedical Engineering
ISSN : 2333-7117
Launched : 2013
Journal of Hematology and Transfusion
ISSN : 2333-6684
Launched : 2013
JSM Environmental Science and Ecology
ISSN : 2333-7141
Launched : 2013
Journal of Cardiology and Clinical Research
ISSN : 2333-6676
Launched : 2013
JSM Nanotechnology and Nanomedicine
ISSN : 2334-1815
Launched : 2013
Journal of Ear, Nose and Throat Disorders
ISSN : 2475-9473
Launched : 2016
JSM Ophthalmology
ISSN : 2333-6447
Launched : 2013
Journal of Pharmacology and Clinical Toxicology
ISSN : 2333-7079
Launched : 2013
Annals of Psychiatry and Mental Health
ISSN : 2374-0124
Launched : 2013
Medical Journal of Obstetrics and Gynecology
ISSN : 2333-6439
Launched : 2013
Annals of Pediatrics and Child Health
ISSN : 2373-9312
Launched : 2013
JSM Clinical Pharmaceutics
ISSN : 2379-9498
Launched : 2014
JSM Foot and Ankle
ISSN : 2475-9112
Launched : 2016
JSM Alzheimer's Disease and Related Dementia
ISSN : 2378-9565
Launched : 2014
Journal of Addiction Medicine and Therapy
ISSN : 2333-665X
Launched : 2013
Journal of Veterinary Medicine and Research
ISSN : 2378-931X
Launched : 2013
Annals of Public Health and Research
ISSN : 2378-9328
Launched : 2014
Annals of Orthopedics and Rheumatology
ISSN : 2373-9290
Launched : 2013
Journal of Clinical Nephrology and Research
ISSN : 2379-0652
Launched : 2014
Annals of Community Medicine and Practice
ISSN : 2475-9465
Launched : 2014
Annals of Biometrics and Biostatistics
ISSN : 2374-0116
Launched : 2013
JSM Clinical Case Reports
ISSN : 2373-9819
Launched : 2013
Journal of Cancer Biology and Research
ISSN : 2373-9436
Launched : 2013
Journal of Surgery and Transplantation Science
ISSN : 2379-0911
Launched : 2013
Journal of Dermatology and Clinical Research
ISSN : 2373-9371
Launched : 2013
JSM Gastroenterology and Hepatology
ISSN : 2373-9487
Launched : 2013
Annals of Nursing and Practice
ISSN : 2379-9501
Launched : 2014
JSM Dentistry
ISSN : 2333-7133
Launched : 2013
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