Prajapat P, Vaghani H, Agarwal S, Talesara GL (2017) Synthetic and Medicinal Chemistry in Drug Discovery: Needs for Today. Ann Med Chem Res 3(1): 1021.

Synthetic organic and medicinal chemistry (Figure 1)

Figure 1: Relation between Synthetic Organic and Medicinal chemistry

is arguably reorienting the field of drug discovery in the same way as one century ago the field of organic chemistry. The area of synthesizing new drugs, their designing, development and application is the most focused and challenging task for the researchers [1]. Drug discovery needs to basic study into the medicinal and chemical nature of the diseased state. For this, specialists from various fields including organic, medicinal chemists and academic researchers are needed. Synthesis of newer organic molecules with more favorable therapeutic properties and their conversion to derivatives which show optimum medicinal activity and synthesize the novel molecule or drug by combining different heterocyclic rings and the synthetic pathway followed, should be economic, safer, less time consuming in order to prepare combinational molecule and also better creation against lethal diseases like malaria, TB, cancer etc. [2,3]. Furthermore, a minor change in chemical structure viz. change in stereochemistry, geometry, functional group, removal of groups, derivative information, oxidation, reduction, hydrogenation, chelate formation, salt formation etc may modify its medicinal activity. The effect of substitution is also of great significance in deciding medicinal activity of a drug. Similarly, drug activity depends upon physical and molecule structure, isosterism, solubility, partition coefficients etc.

The current methods aid and expand experimental approaches to drug design, but are still often not accurate enough to replace experimental methods. Therefore, there is an ongoing and pressing need for improved methodology, and tremendous development efforts are ongoing in the synthetic organic chemistry [4]. Hence, the drug discovery (Figure 2)

Figure 2: Drug discovery cycle

of well-organized synthetic approaches allowing rapid access to miscellaneous series of molecular hybrids must be further investigated by chemist and researchers. Thus, today needs to develop new rapid, convenient, selective, clean synthetic routes (greener approach) and new information, newer scaffolds in chemical encyclopedia and idea about reaction mechanism which helps the drug discovery in medicinal chemistry. Finally, medicinal active molecular hybrids will continue to give strong impetus for discovery of novel chemical reactions, due to the value implicit in providing a molecule for study [5,6].

I thankful to chemistry staff members of the Mehesana Urban Institute of Sciences, Ganpat University, Gujarat for support.

1. Perez-Nueno V. Towards the integration of Quantitative and Pharmacology into Drug Discovery: a systems level understanding of therapeutic and toxic effects of drugs. Curr Pharm Des. 2016; 22: 6881-6884.

2. Patel HM, Noolvi MN, Sharma P, Jaiswal V, Bansal S, Lohan S, et al. Quantitative structure–activity relationship (QSAR) studies as strategic approach in drug discovery. Med Chem Res. 2014; 23: 4991- 5007.

3. Gervais B. An overview of molecular hybrids in drug discovery. Expert Opin on Drug Discov. 2016; 11: 281-305.

4. Shivaputra AP. Role of Medicinal Chemist in the Modern Drug Discovery and Development. Organic Chem Curr Res. 2012; 1: 3.

5. David PR. The critical role of organic chemistry in drug discovery. ACS Chem Neurosci. 2016; 7: 1315-1316.

6. Jean YT, Pablo C. Synthetic biology for pharmaceutical drug discovery. Drug Des Devel Ther. 2015; 9: 6285-6302.