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Journal of Cancer Biology and Research

Assessment of Breast Cancer Treatment Delay Impact on Prognosis and Survival: a Look at the Evidence from Systematic Analysis of the Literature.

Research Article | Open Access

  • 1. Department of Surgery, Washington University, USA
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Corresponding Authors
Faustine Williams, Department of Surgery, Washington University, Social System Design Lab, George Warren Brown School of Social Work, 660 South Euclid Avenue, Campus Box 8100, St. Louis, MO 63110, USA
Absract

Introduction: Breast cancer has remained the most commonly diagnosed disease  among women globally. Despite the advancement in biomedical sciences leading to  improve survival outcomes, some patients endure longer wait periods prior to initiation  of treatment.
Objective: To elucidate the impact of treatment delay on breast cancer patient’s  quality of life and survivorship. Second was to determine the optimal length of time   (delay) between breast cancer diagnosis and start of first treatment in order to  improve prognosis and general health and well-being of survivors.
Methods: Systematic search of the literature was conducted across five electronic  databases: Pub Med, EMBASE, CINAHL, Scopus and Science Direct as well as the  reference list of all articles retrieved.
Results: A total of 33 articles were included in the evidence based systematic  review, which comprised of 255,366 observations. The results of the studies were  categorized under five main themes as: study characteristics, cancer staging and  classification, treatment delay time definition and interval, treatment regimen  classification and delay impact on quality of life and survival. Analyzed wait times from   diagnosis to the initiation of first therapy ranged from 7 days to a period of over 180  days. Combinations of standardized treatment including loco-regional radiotherapy,  systemic chemotherapy surgery as well as hormonal therapy were examined. Even  though some of the studies showed mixed results, overall, findings indicated that early  detection, diagnosis and initiation of treatment within 90 days increase survival.
Conclusions: Evidence revealed that delaying the initiation of treatment for  breast cancer more than 90 days after diagnosis has a detrimental effect on disease  free and overall well-being of survivors.

Williams F (2015) Assessment of Breast Cancer Treatment Delay Impact on Prognosis and Survival: a Look at the Evidence from Systematic Analysis of the Literature. A Pilot Study. J Cancer Biol Res 3(4): 1071.

Received : 02 Nov 2015
Accepted : 02 Dec 2015
Published : 04 Dec 2015
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