Impact of Cognitive Deficits in Patients with Cirrhosis and Alcoholic Hepatopathy after Reduction in Alcohol Intake
- 1. Department of Neuroscience and Behavior, University of São Paulo, Brazil
- 2. National Institute for Translational Medicine, Brazil
CITATION
Donadon MF, Hallak JEC, Osório FL (2016) Impact of Cognitive Deficits in Patients with Cirrhosis and Alcoholic Hepatopathy after Reduction in Alcohol Intake. J Subst Abuse Alcohol 4(2): 1047.
DEAR EDITOR
The excessive use of alcohol is known to favor the occurrence of specific neurocognitive deficits affecting psychomotricity, executive and visuospatial functions like memory, and social cognition [1,2]. In addition, facial emotion recognition (FER), which is in the domain of social cognition, is a key process in social functioning that also seems to be affected by the excessive use of alcohol [3-5].
In a recent study, we assessed for the first time a sample of active alcoholics and found the same global deficits already reported in respect to alcoholics in abstinence or detoxification, as well as specific deficits that appeared as risk factors for the alcohol dependence, considering that alcohol dependence has a direct association with clinical hepatic conditions [6] and that dependence itself may cause alterations in different cognitive functions. Hepatic encephalopathy, for example, causes a number of alterations and deficits in the CNS that can be reverses in cases of successful treatment or liver transplant [7,8].
Based on the sample of subjects with alcohol dependence assessed in our previous study we investigated the associations between FER and different clinical variables including the duration and quantity of alcohol intake and the type of liver disease. From 110 subjects assessed and diagnosed through the Structured Clinical Interview of the Diagnostic and Statistical Manual of Mental Disorders (SCID-IV), 77.35% (n=85) of patients with alcohol dependence had a diagnosis of cirrhosis of the liver and 22.7% (n=25) had alcoholic hepatopathy.
We found that patients with cirrhosis of the liver had a better performance in different parameters of the FER test compared to those with alcoholic hepatopathy, namely, shorter total reaction time (p<0.01), and increased recognition accuracy (p=0.003), especially for sad (p=0.09) and fearful (p=0.01) expressions Conversely, we found that the mean alcohol intake was lower in subjects with cirrhosis (X=7.46; SD=4.76) compared to patients with alcoholic hepatopathy (X=8.24; SD=3.82), although these differences were not statistically significant (U=914.50; p=0.28), possibly because of the sample size.
This finding is quite interesting if we consider the existing literature, since individuals with cirrhosis tend to have greater impairments in cognitive function in relation to patients with alcoholic hepatopathy, as the latter is a less severe clinical condition [9-11]. Conversely, it is noteworthy that this group of patients with liver cirrhosis who have better performance tend to use less quantities of alcohol.
Our interpretation was that alcohol hepatotoxicity, due to causing structural and functional alterations in the liver that include a decrease in enzymes that metabolize alcohol, favors lower intake rates [12,13]. This reduction in alcohol intake (although not statistically significant) may have had a positive effect on the performance of the FER task, suggesting the possibility of the reversal of cognitive impairments even in the presence of a chronic liver disease.
We believe that studies involving larger samples of patients with different liver diseases are opportune and may lend support to the findings presented. Important data could be provided through the assessment of additional clinical indicators (such as intellectual level and hepatoxicity), as well as by cohort studies making longitudinal assessments of performance in FER tasks as a function of alcohol intake and the evolution of liver conditions.