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  • ISSN: 2373-9282
    Early Online
    Volume 7, Issue 1
    Research Article
    Happyness J. Mshana*, Savael X. Ngowi, Vito Baraka, Gerald Misinzo, and Williams H. Makunde
    Background: Bancroftian filariasis a parasitic vector-borne disease among the communicable neglected tropical infectious disease. The disease has been found to compromise the well-being of large populations in endemic countries within the tropics and sub-tropics. Despite of the several studies attempted to document on the mechanism involved in the development of clinical disease, until now the pathogenesis of the disease is not yet clear to date, although there, several underlined aetiological factors being implicated. This study was conducted to determine the role of TLR 2 196 to 173 del and its association with asymptomatic bancroftian filariasis in endemic communities of Tanga region in north eastern Tanzania.
    Methods: TLR 2 -196 to -173 polymorphism in the 5 untranslated region using allele specific real time -polymerase chain reaction (RT-PCR) were tested in 79 individuals.
    Results: TLR 2 -196 to 173 polymorphisms were tested positive in 36.7 % of the samples.
    Conclusion: TLR 2 -196 to -173 del polymorphisms occurrence among individuals infected with bancroftian filariasis disease highlights the potential for the susceptibility of bancroftian filariasis infection and importance of further genetic research for better understanding the mechanism of infection transmission and heterogeneity of the disease.
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