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  • ISSN: 2373-9282
    Early Online
    Volume 7, Issue 1
    Research Article
    Happyness J. Mshana*, Savael X. Ngowi, Vito Baraka, Gerald Misinzo, and Williams H. Makunde
    Background: Bancroftian filariasis a parasitic vector-borne disease among the communicable neglected tropical infectious disease. The disease has been found to compromise the well-being of large populations in endemic countries within the tropics and sub-tropics. Despite of the several studies attempted to document on the mechanism involved in the development of clinical disease, until now the pathogenesis of the disease is not yet clear to date, although there, several underlined aetiological factors being implicated. This study was conducted to determine the role of TLR 2 –196 to –173 del and its association with asymptomatic bancroftian filariasis in endemic communities of Tanga region in north eastern Tanzania.
    Methods: TLR 2 -196 to -173 polymorphism in the 5’ untranslated region using allele specific real time -polymerase chain reaction (RT-PCR) were tested in 79 individuals.
    Results: TLR 2 -196 to – 173 polymorphisms were tested positive in 36.7 % of the samples.
    Conclusion: TLR 2 -196 to -173 del polymorphisms occurrence among individuals infected with bancroftian filariasis disease highlights the potential for the susceptibility of bancroftian filariasis infection and importance of further genetic research for better understanding the mechanism of infection transmission and heterogeneity of the disease.
    Mini Review
    Robb E. Moses* and Bert W. O’Malley
    Dementia is an increasing health problem in an aging population with over 10 million patients with the diagnosis in the US. In the several disease variations characterized by dementia there are common clinical and histological findings, suggesting shared underlying neuronal deficiencies and clinical outcome. Observations support the notion that any of several mechanisms may cause a loss of neuron function, progressing to dementia. In this review we summarize evidence leading to the conclusion that defects in separate neuronal processes are additive, leading to the clinical manifestation of dementia as a result of cumultive defects in discrete cellular functions. Therefore we conclude that the manifstations of dementia are the result of an intersection of defects.
    Review Article
    Dominika Szadkowska* and Wojciechbielecki
    The purpose of this article is to present the issue of spontaneous pituitary tumors in rats. These are non-metastatic tumors made of pituitary glandular cells and are a common health problem in this species. Depending on age, gender and strain, prevalence may reach 100%. The process of their formation is complex - molecular genetic changes initiate the transformation of cells, and hormones and growth factors play an important role in stimulating their proliferation. A commonly used classification of pituitary tumors is that created by WHO. It is based on the determination of the pituitary glandular cell lines using markers such as hormones and transcription factors. Clinical symptoms can be divided into two groups - neurological and hormonal. Neurological symptoms result from tumor growth and pressure on surrounding structures in the brain. Hormonal symptoms occur as a result of hypothalamic-pituitary axis disorder. Diagnosis in veterinary medicine is usually based on medical history and clinical examination, but additional tests such as CT or MRI can also be used. Bromocriptine and cabergoline are used to treat pituitary tumors in rats. Research on potential markers has been ongoing for years, including p53, Ki-67, MMP-9 or PTTG, however, so far, the results of the research remain ambiguous.
    Case Report
    Marcelo Corti*, Astrid Pavlosky, and Marina Narbaitz
    Primary gastric non-Hodgkin lymphoma is a severe complication during the clinical course of human immunodeficiency virus infection. Clinical presentation includes symptoms associated with the upper digestive tract and “B” symptoms (fever, night sweats and weight loss). Endoscopic findings can reveal polypoid, ulcero-infiltrative or ulcer lesions. Multiple biopsy smears are necessary to determine histopathological subtypes. Diffuse large B cell lymphoma (DLBCL) is the most common histopathological subtype in HIV/AIDS patients followed by Burkitt's lymphoma and plasmablastic lymphoma. Chemotherapy plus highly active antiretroviral therapy is the best treatment to achieve a complete remission with prolonged survival in this kind of patients.
    Here we present an HIV seropositive patient who developed a primary gastric DLBCL as second AIDS-defining neoplasm during HAART therapy and after three years of successfully controlling HIV-viral load. Patient presented with a past history of anal squamous cell carcinoma several years before and gastro esophageal reflux disease treated for a long time with omeprazole. He presented with epigastric pain, nausea and dyspepsia. Upper gastrointestinal endoscopy showed erosive gastritis and a large gastric ulcer at the minor gastric curvature. Microscopy examination and immunohistochemistry of the biopsy smears of the large ulcer biopsy confirm the diagnosis of primary gastric DLBCL. He was treated with HAART plus chemotherapy with a complete remission for a time of three years.
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